Severity of Alopecia Predicts Coronary Changes and Arterial Stiffness in Untreated Hypertensive Men

July 2016 in “ Journal of Clinical Hypertension ”

Helen Triantafyllidi, Agis Grafakos, Ignatios Ikonomidis, George Pavlidis, Paraskevi Trivilou, Antonios Schoinas, John Lekakis

androgenic alopecia AGA pulse wave velocity pulse pressure carotid intima-media thickness left ventricular hypertrophy coronary flow reserve aortic stiffness coronary microcirculation male pattern baldness

Studysummary This study found that hypertensive patients with severe androgenic alopecia exhibited impaired coronary microcirculation, suggesting they may face increased cardiovascular risk.

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research Androgenetic Alopecia Is Associated With Increased Arterial Stiffness in Asymptomatic Young Adults

14 citations , March 2014 in “Journal of The European Academy of Dermatology and Venereology”

This study found that androgenetic alopecia in asymptomatic young men was associated with increased arterial stiffness, as measured by the cardio-ankle vascular index.

research Androgenetic Alopecia as an Early Marker for Hypertension

7 citations , January 2013 in “Egyptian Journal of Dermatology and Venereology”

This study found that male patients with androgenetic alopecia had significantly higher aldosterone levels and blood pressure compared to controls, suggesting a possible link between AGA and hypertension.

research Hypertension and Aldosterone Levels in Women with Early-Onset Androgenetic Alopecia

45 citations , November 2009 in “British Journal of Dermatology”

This study found that women with early-onset androgenetic alopecia had higher aldosterone levels and blood pressure, suggesting a possible link to the increased prevalence of hypertension in this group.

research Elevated Aldosterone Levels in Patients with Androgenetic Alopecia

30 citations , June 2009 in “British Journal of Dermatology”

This study suggests that elevated aldosterone may contribute to androgenic alopecia development and its association with higher hypertension prevalence, emphasizing the importance of blood pressure screening in affected patients.

research Is Androgenetic Alopecia a Risk for Atherosclerosis?

38 citations , February 2009 in “Journal of The European Academy of Dermatology and Venereology”

This study found that patients with severe vertex pattern androgenetic alopecia had significantly higher carotid intima-media thickness, suggesting an increased risk of subclinical atherosclerosis compared to other alopecia patterns and healthy controls.

Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations , August 2007 in “American Journal of Pathology”

This study found that overexpression of the mineralocorticoid receptor in a mouse model led to premature epidermal barrier development, keratinocyte apoptosis, and postnatal alopecia, indicating new roles for MR signaling in skin physiology.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Early Androgenetic Alopecia as a Marker of Insulin Resistance