TLDR Men with severe early-onset baldness may have worse heart artery function and stiffer arteries if they have high blood pressure.
The study examined the link between the severity of androgenic alopecia (AGA) and cardiovascular damage in 101 newly diagnosed, untreated hypertensive men. Participants were categorized based on their AGA severity into mild to moderate AGA, severe AGA, and non-AGA groups. Cardiovascular parameters measured included pulse wave velocity, pulse pressure, carotid intima-media thickness, left ventricular hypertrophy, and coronary flow reserve. The findings indicated that coronary flow reserve was significantly lower in the severe AGA group compared to the other groups, while no differences were observed in the other cardiovascular parameters. The severity of AGA was independently associated with coronary flow reserve and pulse pressure, and the duration and onset age of AGA were linked to coronary flow reserve and pulse pressure, respectively. The conclusion was that severe AGA may signal impaired coronary microcirculation and aortic stiffness in hypertensive patients, potentially increasing their cardiovascular risk, especially in those with severe and early-onset AGA.
14 citations,
March 2014 in “Journal of The European Academy of Dermatology and Venereology” Young adults with hair loss face higher risk of stiff arteries.
7 citations,
July 2013 in “Egyptian Journal of Dermatology and Venereology” 
45 citations,
November 2009 in “British Journal of Dermatology” Women with early hair loss have higher blood pressure and aldosterone; screening and treatment may help.
30 citations,
November 2009 in “British Journal of Dermatology” Higher aldosterone levels link to hair loss and high blood pressure.
38 citations,
February 2009 in “Journal of The European Academy of Dermatology and Venereology” Severe vertex pattern hair loss may indicate a higher risk for artery plaque buildup.
67 citations,
August 2007 in “American Journal of Pathology” Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.
195 citations,
July 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
115 citations,
September 2000 in “The Lancet” Early hair loss may indicate risk of insulin resistance.
50 citations,
December 1998 in “Dermatologic Surgery” Hair loss is more common in men aged 18-49 and increases with age.
Early-onset baldness is linked to genetics, lifestyle, and can indicate higher risk for heart and metabolic diseases, and affects mental health.
13 citations,
November 2015 in “Blood Pressure” Hair loss may indicate higher heart risk and metabolic issues.
January 2015 in “Ankara Üniversitesi Tıp Fakültesi mecmuası” Men with severe hair loss may have a higher risk of heart disease.
April 2020 in “Journal of the Endocrine Society” Male pattern baldness may indicate arterial stiffness in transgender men on long-term testosterone therapy.
26 citations,
August 2008 in “Clinical endocrinology” The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.
