Polycystic Ovary Syndrome (PCOS) Trilogy: A Translational and Clinical Review

    August 2008 in “ Clinical endocrinology
    Helen Mason, Annamaria Colao, Ulrike Blume‐Peytavi, Suman Rice, Asjid Qureshi, Laura Pellatt, Francesco Orio, Stephen L. Atkin
    TLDR The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.
    The review on polycystic ovary syndrome (PCOS) highlighted its complex nature, involving chronic anovulatory infertility, hyperandrogenaemia, and symptoms like oligomenorrhoea, hirsutism, and acne. Key findings included increased follicle number and androgen production, with genetic links to chromosome 19. Cardiovascular risks were significant, with increased left ventricular mass, higher diastolic blood pressure, and arterial stiffness, often linked to insulin resistance and hyperandrogenism. Dermatologically, PCOS was the leading cause of hirsutism, managed through various non-pharmacological and pharmacological treatments. Treatments for acne and androgenetic alopecia included hormonal therapies and topical agents. The review underscored the need for further genetic studies and long-term data on cardiovascular outcomes to improve treatment strategies.
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