Obesity and Polycystic Ovary Syndrome

January 2021 in “ Clinical Endocrinology ”

Thomas M. Barber, Stephen Franks

polycystic ovary syndrome PCOS hyperandrogenism insulin resistance troglitazone

Studysummary This review discusses the impact of weight gain and obesity on the development of polycystic ovary syndrome and explores lifestyle strategies to manage the condition, without reporting new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies

129 citations , January 2019 in “Clinical medicine insights”

This review discusses the mechanisms linking obesity and polycystic ovary syndrome and explores potential management options, but it presents no original research findings.

Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

research Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

308 citations , December 2018 in “PLOS Genetics”

This study identified three novel genetic loci associated with PCOS and found similar genetic architecture across different diagnostic criteria, with evidence suggesting genetic links between PCOS and various metabolic and psychological traits.

research Sex Hormone-Binding Globulin: An Important Biomarker for Predicting PCOS Risk - A Systematic Review and Meta-Analysis

91 citations , December 2017 in “Systems Biology in Reproductive Medicine”

This meta-analysis found that lower serum SHBG levels are associated with an increased risk of PCOS, and improving SHBG levels through treatment may reduce PCOS complications.

research Divergences in Insulin Resistance Between the Different Phenotypes of Polycystic Ovary Syndrome

4 citations , September 2013 in “Expert Review of Endocrinology & Metabolism”

Different types of polycystic ovary syndrome show varying levels of insulin resistance, with the 'PHO' type being the most insulin resistant.

research Prevalence of Functional Disorders of Androgen Excess in Unselected Premenopausal Women: A Study in Blood Donors

70 citations , February 2012 in “Human Reproduction”

This study found a high prevalence of clinical signs and functional disorders of androgen excess in premenopausal women, with idiopathic hyperandrogenism and idiopathic hirsutism rates similar to PCOS.

research Treatment of Obstructive Sleep Apnea Improves Cardiometabolic Function in Young Obese Women with Polycystic Ovary Syndrome

105 citations , February 2011 in “The Journal of Clinical Endocrinology & Metabolism”

Treating sleep apnea in young obese women with PCOS can improve heart health and insulin sensitivity.

research Patterns of Ovarian Morphology in Polycystic Ovary Syndrome: A Study Utilizing Magnetic Resonance Imaging

36 citations , November 2009 in “European Radiology”

This study reported that MRI-based ovarian morphology shows significant overlap between PCOS cases and controls, highlighting the need to consider clinical and biochemical data alongside imaging findings for PCOS diagnosis.

Serum Levels of Retinol-Binding Protein 4 and Adiponectin in Women with Polycystic Ovary Syndrome: Associations with Visceral Fat but No Evidence for Fat Mass-Independent Effects on Pathogenesis in This Condition

research Serum Levels of Retinol-Binding Protein 4 and Adiponectin in Women with Polycystic Ovary Syndrome: Associations with Visceral Fat but No Evidence for Fat Mass-Independent Effects on Pathogenesis in This Condition

44 citations , April 2008 in “The Journal of Clinical Endocrinology & Metabolism”

This study concluded that although RBP4 and adiponectin levels are associated with visceral fat, they do not independently contribute to the development of PCOS.

research Global Adiposity Rather Than Abnormal Regional Fat Distribution Characterizes Women with Polycystic Ovary Syndrome

149 citations , December 2007 in “The Journal of Clinical Endocrinology and Metabolism”

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

research Abdominal Fat Quantity and Distribution in Women with Polycystic Ovary Syndrome and Its Relation to Insulin Resistance

270 citations , April 2007 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that PCOS patients had higher amounts of central abdominal fat compared to weight-matched controls, which was associated with increased insulin resistance.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations , December 2003 in “Human Reproduction”

This review discusses the evolution of diagnostic criteria for polycystic ovary syndrome and emphasizes its association with various metabolic and cardiovascular risks, but it provides no new research findings.

research A Prospective Study of the Prevalence of Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain

298 citations , July 2000 in “The Journal of Clinical Endocrinology and Metabolism”

This study found a 6.5% prevalence of polycystic ovary syndrome among a population of Caucasian women in Spain, based on specific endocrine criteria.

research Polycystic Ovary Syndrome: Clinical and Biochemical Features

1947 citations , September 1995 in “New England journal of medicine/The New England journal of medicine”

This article discusses the heterogeneity of polycystic ovary syndrome, its association with insulin resistance, and its implications for long-term health, but reports no new clinical results.