Sex Hormone-Binding Globulin: An Important Biomarker for Predicting PCOS Risk - A Systematic Review and Meta-Analysis

    December 2017 in “ Systems Biology in Reproductive Medicine ”
    Ritu Deswal, Arun Kumar Yadav, Amita Suneja Dang
    Image of study
    TLDR Lower SHBG levels may increase the risk of PCOS.
    The systematic review and meta-analysis from December 11, 2017, found that lower levels of sex hormone-binding globulin (SHBG) are significantly associated with an increased risk of polycystic ovary syndrome (PCOS) and its related metabolic and endocrine disturbances. Analyzing 62 articles, the study showed that SHBG levels were significantly higher in controls compared to PCOS patients, with a standardized mean difference (SMD) of -0.83 (95% CI: -1.01 to -0.64). The review also indicated that therapeutic interventions could improve SHBG levels in PCOS patients, potentially reducing complications associated with the condition. Despite the presence of publication bias and high heterogeneity among the studies, the document suggests that SHBG could serve as a useful biomarker for predicting PCOS risk and may help in understanding the link between PCOS and its associated comorbidities.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 967 results

      community 26M Baseline blood work done before Finasteride

      in Finasteride/Dutasteride  6 upvotes 3 years ago
      A person considering finasteride for hair loss checked their hormone levels before starting treatment. They are concerned about the potential increase in estradiol and its effects, as well as the impact on their sex hormone-binding globulin (SHBG) and free testosterone levels.

      community Hormone tests to decide on oral fin

      in Finasteride/Dutasteride  3 upvotes 1 week ago
      The conversation discusses starting low-dose oral finasteride for hair loss, considering hormone levels and potential side effects like gynecomastia. Suggestions include using DIM for estradiol, vitamin B6 for prolactin, and lifestyle changes to optimize hormone profiles before starting treatment.

      community Pre-Finisteride DHT & Hormone Blood Panel

      in Finasteride/Dutasteride  3 upvotes 1 month ago
      The conversation discusses the cost and insurance coverage of a comprehensive hormone and DHT blood panel for hair loss, with a focus on finasteride treatment. The user seeks a cheaper alternative to a $700 panel recommended in a video.

      community Interpreting pre-finisteride blood panels

      in Chat  2 upvotes 1 month ago
      The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

    Similar Research

    5 / 1000+ results