Sex Hormone-Binding Globulin: An Important Biomarker for Predicting PCOS Risk - A Systematic Review and Meta-Analysis

December 2017 in “ Systems Biology in Reproductive Medicine ”

Ritu Deswal, Arun Kumar Yadav, Amita Suneja Dang

sex hormone-binding globulin SHBG polycystic ovary syndrome PCOS biomarker endocrine disturbances metabolic disturbances

Studysummary This meta-analysis found that lower serum SHBG levels are associated with an increased risk of PCOS, and improving SHBG levels through treatment may reduce PCOS complications.

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Research cited in this study

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research Common Variants in the Sex Hormone-Binding Globulin Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome

24 citations , November 2015 in “Annals of Nutrition and Metabolism”

This study found that specific SHBG gene variants and haplotypes are associated with polycystic ovary syndrome, suggesting that SHBG may be a candidate gene for the condition.

The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

research The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

221 citations , January 2014 in “Human Reproduction”

This study found that the prevalence of polycystic ovary syndrome was 16.6% with Rotterdam criteria but decreased to 6.3% or 8.5% when using alternative criteria involving antral follicle count or anti-Müllerian hormone.

research Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline

1265 citations , October 2013 in “The Journal of Clinical Endocrinology and Metabolism”

This guideline from the Endocrine Society recommends using the Rotterdam criteria for diagnosing polycystic ovary syndrome and outlines first-line treatments, emphasizing hormonal contraceptives and lifestyle intervention.

research Common Variants in the Sex Hormone-Binding Globulin Gene (SHBG) and Polycystic Ovary Syndrome (PCOS) in Mediterranean Women

39 citations , September 2012 in “Human Reproduction”

This study found that specific SHBG gene variants, rs727428 and rs6259, were associated with PCOS in Mediterranean women, although the associations were relatively weak and do not indicate a causative role.

research Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis

991 citations , January 2011 in “Nature Reviews Endocrinology”

This paper reviews the diagnostic criteria, associated morbidities, and possible evolutionary advantages of polycystic ovary syndrome, but does not report any new findings.

research The Effect of Weight Loss and Treatment with Metformin on Serum Vaspin Levels in Women with Polycystic Ovary Syndrome

38 citations , January 2011 in “Endocrine Journal”

This study found that serum vaspin levels were elevated in women with polycystic ovary syndrome compared to controls, but treatment with metformin or weight loss did not significantly change these levels.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

Low Sex Hormone-Binding Globulin Is Associated With Low High-Density Lipoprotein Cholesterol And Metabolic Syndrome In Women With Polycystic Ovary Syndrome

research Low Sex Hormone-Binding Globulin Is Associated With Low High-Density Lipoprotein Cholesterol And Metabolic Syndrome In Women With Polycystic Ovary Syndrome

71 citations , June 2006 in “Human Reproduction”

This study found that in young Taiwanese women with PCOS, low sex hormone-binding globulin levels were associated with low HDL cholesterol levels, independent of insulin resistance and obesity.