Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry

    January 2014 in “ Journal of Proteome Research ”
    Xinjie Zhao, Fang Xu, Bing Qi, Songli Hao, Yanjie Li, Yan Li, Lihong Zou, Chin-Song Lu, Guowang Xu, Lihui Hou
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    TLDR Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.
    The study investigated the serum metabolic characteristics of women with polycystic ovary syndrome (PCOS) using a non-targeted metabolomics approach, analyzing 131 discovery phase samples and 109 validation phase samples from both PCOS patients and healthy controls. Significant metabolic differences were found between the two groups, including altered levels of unsaturated free fatty acids, fatty acid amides, sulfated steroids, glycated amino acids, lysophosphatidylcholines, and lysophosphatidylethanolamines, suggesting abnormalities in lipid and androgen metabolism, increased stearoyl-CoA desaturase activity, and accumulation of advanced glycation end-products in PCOS patients. The researchers identified a combination of five metabolites as potential diagnostic biomarkers for PCOS, with high accuracy in both the discovery (AUC of 0.839) and validation (AUC of 0.874) phases, offering new insights into the pathogenesis of PCOS and a possible diagnostic tool.
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