TLDR Certain metabolites are lower in women with PCOS and could be potential markers for the condition.
In a pilot study with 12 women diagnosed with polycystic ovary syndrome (PCOS) and 10 healthy controls, researchers used hydrogen-1 nuclear magnetic resonance (1H NMR) spectroscopy to compare metabolomic profiles. The study initially found no clear differences, but after applying partial least-squares discriminant analysis (PLS-DA) and non-parametric univariate analysis, a model was created that differentiated the PCOS group from the controls with 90% accuracy. Significant decreases in metabolites such as citrulline, lipids, arginine, lysine, ornithine, proline, glutamate, acetone, citrate, and histidine were observed in the PCOS group. These metabolites could serve as potential biomarkers for PCOS, although the findings need validation in larger studies. The study also emphasized the need to integrate metabolomic data with other biological data for a comprehensive understanding of PCOS and suggested controlling for confounding factors like menstrual cycle phase in future research. Ethnicity did not affect the metabolic profile in this cohort. Despite its small sample size, the study provided preliminary data that could help in future research and improve patient care for women with PCOS.
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23 citations,
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May 2017 in “Human Reproduction Update” The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.
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36 citations,
May 2021 in “Nutrients” Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.
65 citations,
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1 citations,
January 2023 in “Metabolites” Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.
