Detection of Urine Metabolites in Polycystic Ovary Syndrome by UPLC Triple-TOF-MS
August 2015
in “
Clinica Chimica Acta
”
TLDR Researchers found potential urine markers for polycystic ovary syndrome, including testosterone-glucuronide and 11α-hydroxyprogesterone, which may help diagnose the condition.
In a study from 2015, researchers analyzed urine samples from 22 women with polycystic ovary syndrome (PCOS) and 15 healthy controls to identify potential biomarkers for PCOS. They used ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) and found 59 metabolites with different concentrations in the PCOS group. Two novel potential biomarkers, testosterone-glucuronide and 11α-hydroxyprogesterone, and four candidate biomarkers—benzofenap, methionyl-phenylalanine, MG(18:4(6Z,9Z,12Z,15Z)/0:0/0:0), and 2-(14,15-epoxyeicosatrienoyl) glycerol—were identified with significant differences. These biomarkers are related to the ovarian cytochrome P450c17a enzyme. The study concluded that larger studies are needed to validate these findings, which could improve understanding and diagnosis of PCOS. The study also suggested that urinary testosterone glucuronide correlates with plasma testosterone, and decreased urinary 11α-hydroxyprogesterone may be linked to inflammation and male-pattern hair loss in PCOS patients.
