Role of Oxidative Stress in Polycystic Ovary Syndrome

May 2010 in “ Current Women's Health Reviews ”

Joo Yeon Lee, Chin-Kun Baw, Sajal Gupta, Nabil Aziz, Ashok Agarwal

oxidative stress Polycystic Ovary Syndrome PCOS hyperandrogenism ovulatory disturbances insulin resistance obesity malondialdehyde MDA protein carbonyl superoxide dismutase SOD glutathione GSH weight management ovulation insulin sensitivity hormonal profiles hyperandrogenemia

TLDR Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

The document from May 1, 2010, reviews the role of oxidative stress in Polycystic Ovary Syndrome (PCOS), a complex condition characterized by symptoms such as hyperandrogenism, ovulatory disturbances, and metabolic issues like insulin resistance and obesity. It discusses the presence of oxidative stress in PCOS patients, evidenced by biomarkers like malondialdehyde (MDA), protein carbonyl, and reduced levels of antioxidants such as superoxide dismutase (SOD) and glutathione (GSH). The review also notes the importance of weight management in improving PCOS symptoms, as even a slight reduction in body weight can significantly improve ovulation, insulin sensitivity, and hormonal profiles. The document concludes that oxidative stress, along with insulin resistance and hyperandrogenemia, are key factors in the etiology of PCOS, and that further research is needed to understand the mechanisms and develop effective treatments. However, the document does not provide specific conclusions from a study or the number of people involved in the research, as it is a review of existing knowledge.

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Research cited in this study

9 / 9 results

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations, October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

research Definitions, Prevalence, and Symptoms of Polycystic Ovaries and Polycystic Ovary Syndrome

278 citations, August 2004 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

Polycystic ovaries are defined by having 12 or more small follicles in each ovary and are found in up to 33% of women, while Polycystic Ovary Syndrome (PCOS) is the most common hormone disorder in women of reproductive age, potentially increasing risk of obesity, diabetes, and heart diseases.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations, February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

research Prevalence of Polycystic Ovaries in Women with Androgenic Alopecia

84 citations, November 2003 in “European journal of endocrinology”

Women with androgenic alopecia are more likely to have polycystic ovaries and higher androgen levels, which may indicate PCOS.

research Androgen Excess Is the Key Element in Polycystic Ovary Syndrome

99 citations, August 2003 in “Fertility and Sterility”

Too much male hormone is the main cause of Polycystic Ovary Syndrome.

research Developmental Origin of Polycystic Ovary Syndrome: A Hypothesis

430 citations, July 2002 in “Journal of Endocrinology”

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

633 citations, September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

PCOS affects a similar percentage of Black and White women in the Southeastern United States.

research Current Concepts of Polycystic Ovary Syndrome

60 citations, June 1997 in “Baillière's clinical obstetrics and gynaecology”

PCOS is often caused by hormonal imbalances that can lead to various health issues and may indicate a risk for future metabolic and cardiovascular problems.

A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

research A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

135 citations, August 1994 in “Clinical Endocrinology”

Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.

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