TLDR Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.
The document from May 1, 2010, reviews the role of oxidative stress in Polycystic Ovary Syndrome (PCOS), a complex condition characterized by symptoms such as hyperandrogenism, ovulatory disturbances, and metabolic issues like insulin resistance and obesity. It discusses the presence of oxidative stress in PCOS patients, evidenced by biomarkers like malondialdehyde (MDA), protein carbonyl, and reduced levels of antioxidants such as superoxide dismutase (SOD) and glutathione (GSH). The review also notes the importance of weight management in improving PCOS symptoms, as even a slight reduction in body weight can significantly improve ovulation, insulin sensitivity, and hormonal profiles. The document concludes that oxidative stress, along with insulin resistance and hyperandrogenemia, are key factors in the etiology of PCOS, and that further research is needed to understand the mechanisms and develop effective treatments. However, the document does not provide specific conclusions from a study or the number of people involved in the research, as it is a review of existing knowledge.
Cited in this study
9 / 9 results
1540 citations
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February 2009 in “Fertility and Sterility” The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.
278 citations
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October 2004 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” Polycystic ovaries are defined by having 12 or more small follicles in each ovary and are found in up to 33% of women, while Polycystic Ovary Syndrome (PCOS) is the most common hormone disorder in women of reproductive age, potentially increasing risk of obesity, diabetes, and heart diseases.
947 citations
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February 2004 in “The Journal of Clinical Endocrinology and Metabolism” Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.
84 citations
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November 2003 in “European journal of endocrinology” Women with androgenic alopecia are more likely to have polycystic ovaries and higher androgen levels, which may indicate PCOS.
99 citations
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August 2003 in “Fertility and Sterility” Too much male hormone is the main cause of Polycystic Ovary Syndrome.
430 citations
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July 2002 in “Journal of Endocrinology” The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.
633 citations
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September 1998 in “The Journal of Clinical Endocrinology and Metabolism” PCOS affects a similar percentage of Black and White women in the Southeastern United States.
60 citations
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June 1997 in “Baillière's clinical obstetrics and gynaecology” PCOS is often caused by hormonal imbalances that can lead to various health issues and may indicate a risk for future metabolic and cardiovascular problems.
135 citations
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August 1994 in “Clinical Endocrinology” Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.
