Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women
May 2017
in “
Human Reproduction Update
”
non-classic congenital adrenal hyperplasia 21-hydroxylase deficiency androgen excess PCOS-like features serum 17-hydroxyprogesterone CYP21A2 glucocorticoids oral contraceptives anti-androgens hirsutism miscarriage risk metabolic issues cardiovascular issues fertility CPA ethinylestradiol dexamethasone LC/MS assays 17-OHP NCAH CYP21A2 gene birth control pills anti-androgen drugs hirsutism treatment miscarriage prevention metabolic health heart health fertility treatment cyproterone acetate ethinyl estradiol liquid chromatography-mass spectrometry
Studysummary This review examines the epidemiology, pathophysiology, diagnosis, and management strategies for non-classic congenital hyperplasia due to 21-hydroxylase deficiency, and provides evidence-based recommendations for its treatment and genetic counseling.
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