Non-Classic Congenital Adrenal Hyperplasia

    April 2013 in “ Steroids ”
    Selma F. Witchel
    Image of study
    TLDR Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.
    In 2013, a review was conducted on Non-classic congenital adrenal hyperplasia (NCAH), a common disorder due to 21-hydroxylase deficiency, with a prevalence of 1 in 1000. The disorder often presents with symptoms of androgen excess, including hirsutism, acne, androgenic alopecia, anovulation, menstrual dysfunction, and infertility. The disorder is caused by mutations in the CYP21A2 gene and is typically diagnosed via an acute ACTH stimulation test. The review emphasized that clinical features should guide management, not just hormonal and molecular findings. Women with NCAH often experience subfertility due to excessive adrenal and ovarian androgen secretion, elevated 17-OHP and progesterone concentrations, and poor self-esteem. The review suggested preconception genetic counseling and glucocorticoids to decrease miscarriage risk. It also mentioned a case where a couple with NCAH achieved pregnancy after 40 days of hydrocortisone treatment. The review also discussed the risk of having a child with CAH, prenatal treatment, and complications such as adrenal tumors and testicular adrenal rest tumors (TARTs).
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Why I deleted my YouTube channel Part I

      in Update  118 upvotes 4 years ago
      A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

      community My First Hair System Experience (photos enclosed)

       14 upvotes 7 years ago
      A user shared their positive experience with a non-surgical hair replacement system, detailing the purchase and maintenance process, including using Walker Lace Front Support Tape and various adhesives. They found the system secure and undetectable, allowing them to engage in active pursuits without issues.

      community It's over. Hairline has fallen. Millions must shave.

      in Update  467 upvotes 2 years ago
      The conclusion of the conversation is that the user has tried various medications and treatments for hair loss, including minoxidil, finasteride, microneedling, and nizoral shampoo, but has not seen any progress. They have decided to shave their head. Other users suggest options such as hair transplants, RU58841, hair units, and scalp micropigmentation.

    Related Research

    2 / 2 results