Non-Classic Congenital Adrenal Hyperplasia

    April 2013 in “ Steroids ”
    Selma F. Witchel
    Image of study
    TLDR Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.
    In 2013, a review was conducted on Non-classic congenital adrenal hyperplasia (NCAH), a common disorder due to 21-hydroxylase deficiency, with a prevalence of 1 in 1000. The disorder often presents with symptoms of androgen excess, including hirsutism, acne, androgenic alopecia, anovulation, menstrual dysfunction, and infertility. The disorder is caused by mutations in the CYP21A2 gene and is typically diagnosed via an acute ACTH stimulation test. The review emphasized that clinical features should guide management, not just hormonal and molecular findings. Women with NCAH often experience subfertility due to excessive adrenal and ovarian androgen secretion, elevated 17-OHP and progesterone concentrations, and poor self-esteem. The review suggested preconception genetic counseling and glucocorticoids to decrease miscarriage risk. It also mentioned a case where a couple with NCAH achieved pregnancy after 40 days of hydrocortisone treatment. The review also discussed the risk of having a child with CAH, prenatal treatment, and complications such as adrenal tumors and testicular adrenal rest tumors (TARTs).
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Why I deleted my YouTube channel Part I

      in Update  118 upvotes 3 years ago
      A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

      community What are these spots on my scalp

      in Treatment  51 upvotes 5 months ago
      A user noticed non-itchy, non-bleeding spots on their scalp while experiencing hair loss. Replies suggest the spots are likely sunspots or liver spots and recommend seeing a dermatologist; hair loss is attributed to male pattern baldness.

      community Losing hair for 3 years (24 yrs old)

      in Chat  26 upvotes 3 years ago
      User losing hair for 3 years tried shampoos, minoxidil, derma rolling, finasteride, and Adegen's 15% minoxidil protocol without success. Another user suggests lowering finasteride dosage and trying topical non-steroidal anti-androgens like Fluridil, RU58841, and Breezula.

      community 2nd day on pyrilutamide - what I noticed so far

      in Treatment  7 upvotes 1 year ago
      The user started using a hair loss treatment called pyrilutamide and experienced mild chest discomfort and tightness, similar to previous side effects from RU58841. They plan to reduce the dosage due to these side effects and will provide an update on the results in 1-2 months.

    Related Research

    2 / 2 results