TLDR A 12-year-old girl with very high testosterone and insulin resistance improved with birth control pills, suggesting PCOS can cause high testosterone without tumors.
The document described a case of a 12-year-old Vietnamese girl with severe hyperandrogenemia and insulin resistance, symptoms often associated with polycystic ovary syndrome (PCOS). She experienced rapid hyperandrogenism and virilization, with symptoms such as hirsutism, a deepened voice, and oligomenorrhea, and had unusually high testosterone levels exceeding 200 ng/dL. Despite no evidence of ovarian or adrenal masses, her condition was successfully managed with continuous combined oral contraceptives (COCs), which significantly reduced her androgen levels. This case emphasized that PCOS can manifest with higher than expected testosterone levels and that severe hyperinsulinemia may contribute to the rapid progression of hyperandrogenism. The patient's quick and significant response to COCs suggested that PCOS should be considered in similar cases, even when high testosterone levels are not tumor-related.
Cited in this study
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1540 citations
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February 2009 in “Fertility and Sterility” The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.
271 citations
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December 2005 in “New England journal of medicine/The New England journal of medicine” The document likely offers guidance on treating a woman's excessive hair growth, considering her symptoms and obesity.
5 citations
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January 2005 in “Dermatology” Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.
2 citations
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August 2012 in “Journal of Pediatric and Adolescent Gynecology” A 12-year-old girl with very high testosterone and insulin resistance improved with birth control pills, suggesting PCOS can cause high testosterone without tumors.
4 citations
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April 2012 in “Our Dermatology Online” The conclusion is that PCOS is a common cause of hirsutism in young obese women, and early treatment is important to reduce the risk of metabolic syndrome.
July 2011 in “Oxford University Press eBooks” The document's conclusion cannot be determined without content to analyze.
75 citations
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June 1999 in “Pediatric Clinics of North America” The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.
