TLDR Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.
In the 2005 study, two young women with primary amenorrhea exhibited unusually high levels of androgens but only mild skin symptoms. The first patient, with vertical alopecia, had a serum dehydroepiandrosterone sulfate level greater than 800 µg/dl, suggesting late-onset, non-classical adrenal hyperplasia. The second patient, with mild acne, had an extremely high serum total testosterone level over 9,000 ng/dl, which was linked to an androgen-secreting adrenal adenoma that overexpressed several steroidogenic enzymes. These cases underscore the importance of thorough history-taking and physical examinations in females with acne or alopecia, and they highlight the need to consider the possibility of an adrenal tumor in patients with significantly elevated testosterone levels.
117 citations,
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January 2003 in “Dermatology” Hormonal therapy is becoming a promising treatment for acne.
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November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
86 citations,
July 2002 in “Clinical and Experimental Dermatology” FPHL is a common, age-related, genetic hair loss with unclear causes and limited treatment options.
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December 2000 in “Archives of Dermatological Research” Androgens significantly affect female hair loss, and hormonal treatments may help.
227 citations,
January 1998 in “Journal of Endocrinology” Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
75 citations,
May 1986 in “Clinics in endocrinology and metabolism” Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.
8 citations,
October 2010 in “Scandinavian Journal of Clinical & Laboratory Investigation” Normal-range ALT levels can indicate metabolic and hormonal imbalances in young women.
January 2019 in “ARC journal of pharmaceutical sciences” Acne can be managed with various treatments and requires psychological support due to its emotional impact.
18 citations,
June 2019 in “Clinical research in dermatology” Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.
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July 2009 in “Journal of Pediatric and Adolescent Gynecology” Quick treatment of hair disorders in teenage girls is important because of the emotional effects.
8 citations,
January 1996 in “Springer eBooks” Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.
