The Diagnosis of Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Based on Serum Basal or Post-ACTH Stimulation 17-Hydroxyprogesterone Can Lead to False-Positive Diagnosis

    September 2015 in “ Clinical Endocrinology ”
    Urszula Ambroziak, Anna Kępczyńska-Nyk, Alina Kurylowicz, E Małunowicz, Anna Wójcicka, Piotr Miśkiewicz, Magdalena Macech
    Image of study
    TLDR Using 17-hydroxyprogesterone levels to diagnose nonclassic congenital adrenal hyperplasia can result in many incorrect diagnoses.
    The study investigated the accuracy of using serum 17-hydroxyprogesterone (170HP) levels to diagnose nonclassic congenital adrenal hyperplasia (NCCAH) in 40 women with hyperandrogenism. It found that relying on 170HP levels, both basal and post-ACTH stimulation, can lead to a high rate of false-positive diagnoses. Out of 21 patients with elevated 170HP levels, only 5 (24%) were confirmed to have NCCAH through additional urinary steroid profile and genetic testing. The study concluded that a definitive diagnosis of NCCAH should not be based solely on 170HP measurements but should be confirmed with more specific tests, as 170HP levels can be misleading.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 811 results

      community 17 month finasteride update (title)

      in Progress Pictures  51 upvotes 2 weeks ago
      The user has been using finasteride since November 2023, which improved their hair and confidence, and they plan to switch to dutasteride and get a hair transplant. They noticed hair thickening after 3-4 months on finasteride and are considering oral dutasteride and minoxidil for further improvement.

      community *17 month update*Before & after pic.

      in Progress Pictures  540 upvotes 2 weeks ago
      The conversation discusses a user's impressive hair regrowth progress over 17 months using a topical minoxidil and finasteride spray from HIMS, with suggestions to add microneedling for better results. Some users express skepticism about the authenticity of the results, while others inquire about side effects and application methods.

      community 17-Month Update - Dut, Min, Niz, 1.5mm roller.

      in Progress Pictures  312 upvotes 1 year ago
      A 39-year-old shared a 17-month hair loss treatment update using Dutasteride, Minoxidil, Nizoral shampoo, and a 1.5mm derma roller, noticing significant results after 9-12 months. They also maintain a healthy lifestyle and manage side effects like dry skin with moisturizer.

      community 17 month update 30M FUT 2300 grafts 1 year fin/min topical

      in Progress Pictures  414 upvotes 1 year ago
      A user shared a 17-month update on their hair loss treatment, which included a hair transplant of 2300 grafts, using a topical solution of minoxidil and finasteride, a laser cap, and ketoconazole shampoo. They are considering another transplant and seeking honest feedback on their progress, while others share their own experiences and advice on hair loss treatments.

    Related Research

    1 / 1 results