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GlossaryNon-Classical Adrenal Hyperplasia (NCCAH)

partial enzyme deficiency causing excess androgen production

Non-Classical Adrenal Hyperplasia (NCAH) is a milder form of congenital adrenal hyperplasia that typically presents later in life, often during adolescence or adulthood. It is caused by a partial deficiency in the enzyme 21-hydroxylase, leading to an overproduction of androgens (male hormones). Symptoms can include irregular menstrual cycles, excessive hair growth (hirsutism), and acne in females, while males may experience early signs of puberty.

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research Recommendations for Treatment of Nonclassic Congenital Adrenal Hyperplasia: An Update

56 citations, December 2011 in “Steroids”

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

research Management of the Female With Non-Classical Congenital Adrenal Hyperplasia: A Patient-Oriented Approach

30 citations, June 2019 in “Frontiers in Endocrinology”

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

research Non-Classical Congenital Adrenal Hyperplasia Presenting With Severe Androgenic Alopecia: A Case Report

February 2025 in “Cureus”

Early diagnosis and treatment of NCCAH can improve symptoms and fertility.

research When Acne, Hirsutism, and Menstrual Irregularities Are More Than PCOS

April 2020 in “Journal of the Endocrine Society”

Non-classic congenital adrenal hyperplasia (NCCAH) can mimic PCOS and requires genetic testing for proper diagnosis and treatment.

research Phenotypic Profiling of Parents With Cryptic Nonclassic Congenital Adrenal Hyperplasia: Findings in 145 Unrelated Families

62 citations, March 2011 in “European journal of endocrinology”

Some parents have a mild form of congenital adrenal hyperplasia without symptoms, and they usually don't need treatment.

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community Why don't more people here use oils?

in Treatment 22 upvotes 5 years ago

The conversation discusses using oils like pumpkin seed, rosemary, peppermint, and grape seed oil for hair regrowth, claiming they can be as effective as finasteride or minoxidil without side effects. Some users remain skeptical and prefer proven treatments like minoxidil.

community Female Hair Loss, Is there anything else I should be doing?

11 upvotes 10 years ago

A 20-year old female experiencing hair loss, who has had normal blood tests and is currently using minoxidil as recommended by her doctor. She is asking if there are any other treatments she should consider.

community I’m already DOING EVERYTHING!!!

in Female 27 upvotes 4 years ago

A 26 year old female dealing with hair loss who is considering treatments such as Spiro, minoxidil and finasteride. Other potential solutions mentioned are PRP treatment, a wig, and bio-identical estrogen combined with bica.