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GlossaryNon-Classical Adrenal Hyperplasia (NCCAH)

partial enzyme deficiency causing excess androgen production

Non-Classical Adrenal Hyperplasia (NCAH) is a milder form of congenital adrenal hyperplasia that typically presents later in life, often during adolescence or adulthood. It is caused by a partial deficiency in the enzyme 21-hydroxylase, leading to an overproduction of androgens (male hormones). Symptoms can include irregular menstrual cycles, excessive hair growth (hirsutism), and acne in females, while males may experience early signs of puberty.

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research Management of the Female With Non-Classical Congenital Adrenal Hyperplasia: A Patient-Oriented Approach

30 citations , June 2019 in “Frontiers in Endocrinology”

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

research Differential Diagnosis of Hyperandrogenism in Women with Polycystic Ovary Syndrome

35 citations , March 2012 in “Experimental and Clinical Endocrinology & Diabetes”

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

research Phenotypic Profiling of Parents With Cryptic Nonclassic Congenital Adrenal Hyperplasia: Findings in 145 Unrelated Families

62 citations , March 2011 in “European journal of endocrinology”

Some parents have a mild form of congenital adrenal hyperplasia without symptoms, and they usually don't need treatment.

The Diagnosis of Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Based on Serum Basal or Post-ACTH Stimulation 17-Hydroxyprogesterone Can Lead to False-Positive Diagnosis

research The Diagnosis of Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Based on Serum Basal or Post-ACTH Stimulation 17-Hydroxyprogesterone Can Lead to False-Positive Diagnosis

25 citations , September 2015 in “Clinical Endocrinology”

Using 17-hydroxyprogesterone levels to diagnose nonclassic congenital adrenal hyperplasia can result in many incorrect diagnoses.

research Challenges in Treatment of Patients With Non-Classic Congenital Adrenal Hyperplasia

4 citations , December 2022 in “Frontiers in Endocrinology”

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

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community I'm already DOING EVERYTHING!!!

in Female 26 upvotes 5 years ago

A 26 year old female dealing with hair loss who is considering treatments such as Spiro, minoxidil and finasteride. Other potential solutions mentioned are PRP treatment, a wig, and bio-identical estrogen combined with bica.

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in Progress Pictures 58 upvotes 8 months ago

The user shared their 6-month progress using finasteride and minoxidil for hair loss, noting improvements and reduced shedding. They decreased their minoxidil dosage from 10% to 5% and no longer need biotin, with no side effects from finasteride.

community Female Hair Loss, Is there anything else I should be doing?

11 upvotes 11 years ago

A 20-year old female experiencing hair loss, who has had normal blood tests and is currently using minoxidil as recommended by her doctor. She is asking if there are any other treatments she should consider.

community Why don't more people here use oils?

in Treatment 21 upvotes 6 years ago

The conversation discusses using oils like pumpkin seed, rosemary, peppermint, and grape seed oil for hair regrowth, claiming they can be as effective as finasteride or minoxidil without side effects. Some users remain skeptical and prefer proven treatments like minoxidil.

community 4 weeks in (dutasteride only).

in Progress Pictures 76 upvotes 4 months ago

A user experienced hairline improvement after four weeks on 1.5mg dutasteride but had side effects like reduced libido and sensitive nipples. They plan to switch to finasteride to manage these side effects.