TLDR Early diagnosis and treatment of NCCAH can improve symptoms and fertility.
This case report describes a 37-year-old female with non-classical congenital adrenal hyperplasia (NCCAH) who presented with severe androgenic alopecia, acne, and primary infertility, despite regular menstrual cycles. Elevated 17a-hydroxyprogesterone (17-OHP) levels confirmed the diagnosis, while other hormone levels were normal. Treatment with prednisolone was used to manage hyperandrogenic symptoms and improve fertility. The report underscores the importance of considering NCCAH in patients with hyperandrogenic symptoms and normal hormonal profiles, highlighting 17-OHP as a crucial diagnostic marker. Early diagnosis and targeted treatment can significantly improve outcomes and address infertility concerns.
157 citations,
May 2021 in “Endocrine Reviews” Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.
February 2020 in “Open Access Macedonian Journal of Medical Sciences” The patient with severe hirsutism improved after being diagnosed with non-classic congenital adrenal hyperplasia and treated with corticosteroids.
30 citations,
June 2019 in “Frontiers in Endocrinology” The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.
1 citations,
August 2012 in “Journal der Deutschen Dermatologischen Gesellschaft” A woman's hyperandrogenism was caused by a genetic mutation leading to non-classic adrenogenital syndrome.
July 2017 in “Contemporary Endocrinology” The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.
88 citations,
April 2017 in “Journal of Pediatric and Adolescent Gynecology” The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.
117 citations,
May 2017 in “Human Reproduction Update” The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.
22 citations,
January 2002 in “Treatments in endocrinology” Birth control pills help treat skin and hair growth problems linked to high male hormone levels.