Non-Classical Congenital Adrenal Hyperplasia Presenting With Severe Androgenic Alopecia: A Case Report

    February 2025 in “ Cureus ”
    Khalid Al Hawsawi, Hamazah Qul, Ameera Alkhamesi, Sarah M Fageeh
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    TLDR Early diagnosis and treatment of NCCAH can improve symptoms and fertility.
    This case report describes a 37-year-old female with non-classical congenital adrenal hyperplasia (NCCAH) who presented with severe androgenic alopecia, acne, and primary infertility, despite regular menstrual cycles. Elevated 17a-hydroxyprogesterone (17-OHP) levels confirmed the diagnosis, while other hormone levels were normal. Treatment with prednisolone was used to manage hyperandrogenic symptoms and improve fertility. The report underscores the importance of considering NCCAH in patients with hyperandrogenic symptoms and normal hormonal profiles, highlighting 17-OHP as a crucial diagnostic marker. Early diagnosis and targeted treatment can significantly improve outcomes and address infertility concerns.
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