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GlossaryStearoyl-CoA Desaturase 1

enzyme converting saturated fatty acids to monounsaturated fatty acids

Stearoyl-CoA Desaturase 1 (SCD1) is an enzyme that plays a crucial role in the metabolism of fatty acids. It converts saturated fatty acids into monounsaturated fatty acids, which are important for maintaining cell membrane fluidity and producing signaling molecules. This enzyme is significant in various biological processes, including lipid metabolism and energy homeostasis, and has been linked to conditions like obesity, diabetes, and certain skin disorders.

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research Obesity Resistance of the Stearoyl-CoA Desaturase-Deficient (Scd1 -/-) Mouse Results from Disruption of the Epidermal Lipid Barrier and Adaptive Thermoregulation

87 citations , March 2007 in “Biological Chemistry”

Deleting the scd1 gene in mice prevents obesity by disrupting skin lipids and improving heat regulation.

research Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

67 citations , December 2013 in “Journal of Biological Chemistry”

SCD1 is crucial for skin health and overall energy balance.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.

research Scd1 ab-Xyk: A New Asebic Allele Characterized by a CCC Trinucleotide Insertion in Exon 5 of the Stearoyl-CoA Desaturase 1 Gene in Mouse

12 citations , July 2004 in “Molecular genetics and genomics”

A new mouse mutation causes skin and hair defects due to a gene change.

research Skin Stearoyl-CoA Desaturase Genes

1 citations , January 2013

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