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Glossary Steroid Sulfatase

enzyme that converts sulfated steroids into active forms

Steroid Sulfatase (STS) is an enzyme that plays a crucial role in the metabolism of steroid hormones by converting sulfated steroid precursors into their active forms. This process is important for the regulation of various physiological functions, including skin health, hair growth, and reproductive processes. Deficiencies or mutations in the STS gene can lead to conditions such as X-linked ichthyosis, which is characterized by dry, scaly skin.

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Research

5 / 1000+ results

research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

451 citations , March 2005 in “Endocrine Reviews”

This paper discusses the role of steroid sulfatase in hormone-dependent tumors and highlights the development of potent inhibitors, noting the commencement of a phase I trial for one inhibitor in postmenopausal breast cancer patients.

research Steroid sulfatase inhibitors

108 citations , April 2004 in “Medicinal Research Reviews”

This review discusses the medicinal chemistry of steroid sulfatase inhibitors for estrogen- and androgen-dependent disorders but reports no new clinical results.

research Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla

61 citations , December 2001 in “Journal of Investigative Dermatology”

This study found that steroid sulfatase in the dermal papilla of hair follicles metabolizes dehydroepiandrosterone sulfate to support the development of androgenetic alopecia, suggesting potential for steroid sulfatase inhibitors as treatments.

research Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty

41 citations , March 2016 in “The Journal of Clinical Endocrinology & Metabolism”

This study suggests that patients with STSD show a different pattern in androgen activation compared to healthy controls, potentially due to increased 5α-reductase activity and absent prepubertal serum DHEA surge.

research Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

37 citations , September 2003 in “Journal of Medicinal Chemistry”

This study found that compound 2g inhibits steroid sulfatase effectively without exhibiting estrogenic activity, making it a promising candidate for breast cancer treatment.

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Community Join

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community The perfect reverse reverse hair-loss nuclear stack for those who feel left out

in Satire 415 upvotes 1 year ago

A satirical discussion on intentionally inducing hair loss using harmful habits and substances like cigarettes, junk food, anabolic steroids, and stress. The conversation humorously suggests extreme measures like chemotherapy and hydrofluoric acid, while also mentioning the ineffectiveness of sulfates and pumpkin seed oil in hair loss prevention.

community Min/fin update and dandruff relief 🙏🏼🙏🏼🙏🏼

4 upvotes 1 month ago

The user experienced solid results with oral minoxidil and finasteride but had to stop topical minoxidil due to severe dandruff. They found relief using Equate dandruff shampoo with menthol selenium sulfate 1%, which helped control the dandruff and reduce hair shedding.

community Reducing Scalp Inflammation

4 upvotes 5 years ago

The conversation discusses treatments for scalp inflammation, suggesting options like scalp massage, changing shampoos, using aloe vera, Tgel, nizoral shampoo, topical cetirizine, and consulting a dermatologist. Finasteride was mentioned as helpful for reducing inflammation, but with side effects.

community 22M Losing hair since 16, nothing helps, scalp always itchy. Just fed up.

in Treatment 59 upvotes 11 months ago

A 22-year-old experiencing hair loss and persistent scalp itchiness since age 16 has tried various treatments, including finasteride, ketoconazole shampoo, and dietary changes, with no success. Suggestions include consulting a knowledgeable dermatologist, considering seborrheic dermatitis, and trying different shampoos like Selsun Blue or those with selenium sulfide.

community Creatine is the opposite of minoxidil !

324 upvotes 11 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

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Learn

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learn Hydrocortisone

Can hydrocortisone be used together with other treatments like minoxidil or steroid injections? If minoxidil solution irritates the scalp, the cause may be irritation, seborrhoeic dermatitis or an allergy to an ingredient, so it is worth having a doctor or pharmacist look before adding a steroid. No verified trial tests hydrocortisone alongside minoxidil or corticosteroid injections, and prolonged scalp use risks skin thinning.

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