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    GlossarySteroid Sulfatase Inhibitors

    block enzyme activity to reduce active steroid levels

    Steroid Sulfatase Inhibitors (STS inhibitors) are compounds that block the activity of the enzyme steroid sulfatase, which is involved in the conversion of sulfated steroid precursors into active steroids like estrogen. By inhibiting this enzyme, STS inhibitors can reduce the levels of active steroids, potentially offering therapeutic benefits in conditions like hormone-sensitive cancers and certain skin disorders.

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      Targets to Treat Androgen Excess in Polycystic Ovary Syndrome

      research Targets to Treat Androgen Excess in Polycystic Ovary Syndrome

      14 citations, September 2015 in “Expert Opinion on Therapeutic Targets”
      The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.
      Sulfatase Inhibitors: A Patent Review

      research Sulfatase Inhibitors: A Patent Review

      47 citations, November 2012 in “Expert Opinion on Therapeutic Patents”
      The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

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