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    Glossary Steroid Sulfatase Inhibitors

    block enzyme activity to reduce active steroid levels

    Steroid Sulfatase Inhibitors (STS inhibitors) are compounds that block the activity of the enzyme steroid sulfatase, which is involved in the conversion of sulfated steroid precursors into active steroids like estrogen. By inhibiting this enzyme, STS inhibitors can reduce the levels of active steroids, potentially offering therapeutic benefits in conditions like hormone-sensitive cancers and certain skin disorders.

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    1. Steroid sulfatase inhibitors Medicinal Research Reviews · 2004 · 108 citations
    2. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 25 citations
    3. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 1 citations
    4. Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2003 · 37 citations
    5. 2-Substituted 4-(Thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2002 · 111 citations
    6. N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase Bioorganic & Medicinal Chemistry Letters · 2004 · 17 citations
    7. Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition Endocrine Reviews · 2005 · 451 citations
    8. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001 · 61 citations
    9. Sulfatase inhibitors: a patent review Expert Opinion on Therapeutic Patents · 2012 · 47 citations
    10. Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination Current Opinion in Chemical Biology · 2008 · 83 citations
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