Steroid Sulfatase Inhibitors: Role and Therapeutic Potential

January 2003 in “ Expert Opinion on Therapeutic Patents ”

Peter Nussbaumer, Andreas Billich

steroid sulfatase inhibitors STS oestrogens androgens androgenic alopecia acne

TLDR Steroid sulfatase inhibitors could potentially treat hormone-related disorders like certain cancers, hair loss, acne, and improve cognitive dysfunction.

The document from 2002 reviewed the role of Steroid sulfatase (STS) and its inhibitors. STS regulates the local production of oestrogens and androgens from systemic precursors in several tissues, catalysing the hydrolysis of the sulfate esters of 3-hydroxy steroids. The enzyme had received attention due to its potential involvement in the pathogenesis of various diseases. STS inhibitors were considered potential therapeutic agents for the treatment of oestrogen- and androgen-dependent disorders, including cancers of the breast, endometrium and prostate, androgenic alopecia, and acne. They were also proposed to have positive effects on cognitive dysfunction. The review summarized patents on STS inhibitors that had appeared since 1999.

View this study on tandfonline.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 502 results

community Oral Minoxidil and Grapefruit Juice

in Research/Science 96 upvotes 1 year ago

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

community Progress o regress? 2 Years only dermaroller (and RU for only 2 month)

in Is this regrowth? 69 upvotes 1 year ago

The conversation discusses hair loss and treatments, with users suggesting the original poster's hair has receded despite using a dermaroller and RU58841 for two months. Many recommend starting finasteride and minoxidil for better results.

community Not sure what else to do, can’t use anti-androgens (Baseline Hormonal Bloodwork included) need advice badly

in Update 6 upvotes 3 years ago

User experienced feminizing side effects from finasteride and tried RU, alfatradiol, and finasteride without success. They are now considering treatments like Stemoxydine, Zix, Minoxidil, Dermarolling, Eucapil, and a hair transplant.

community Finasteride only reduces scalp DHT by ~40%. Why does it work?

in Finasteride/Dutasteride 37 upvotes 1 year ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

community What do these pictures say about my hair and scalp if anything? Miniaturization, inflammation, etc.?

in Research/Science 74 upvotes 2 years ago

Hair loss and scalp issues, with people discussing possible treatments such as Nizoral shampoo, Minoxidil, neem oil, and finasteride.

community Minoxidil seems to not work anymore this sucks

in Progress Pictures 32 upvotes 1 year ago

A user reported that Minoxidil, a hair growth treatment, stopped working for them despite initial success. Other users suggested not taking breaks from the treatment, checking for fake products, trying microneedling, using oral Minoxidil, combining Minoxidil with tretinoin, and using finasteride.

Related Research

1 / 1 results

research Steroid Sulfatase Inhibitors: Therapeutic Applications and Development

25 citations, May 2003 in “Expert Opinion on Therapeutic Patents”

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.