Steroid Sulfatase Inhibitors: Therapeutic Applications and Development

    May 2003 in “ Expert Opinion on Therapeutic Patents ”
    Peter Nussbaumer, Andreas Billich
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    TLDR Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.
    The 2003 document reviewed the role and potential therapeutic applications of Steroid Sulfatase (STS) inhibitors in various diseases, including hormone-dependent disorders like cancers, androgenic alopecia, and acne. STS inhibitors were seen as promising for treating these conditions by reducing local hormone production. The most advanced preclinical development of STS inhibitors was for breast cancer, with 667COUMATE identified as a candidate for clinical trials. The document also discussed the design of new inhibitors, considering potential estrogenicity and chemical stability. However, the document did not provide specific numbers of people involved in the studies, limiting the strength of the conclusions.
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