21M Started young, treated early, but non-responder to dht blockers 7/4/2025
A 21-year-old male uses minoxidil, finasteride, and dutasteride for hair loss but still experiences progression with high DHT levels. Suggestions include increasing dosages, checking for deficiencies, considering a hair system, or consulting a specialist.
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5 / 5 resultscommunity How come topical finasteride even works at all?
Topical finasteride can effectively reduce scalp DHT by targeting local enzymes, despite less systemic impact compared to oral forms. Combining oral dutasteride with topical finasteride and minoxidil may enhance hair loss prevention, though evidence of its effectiveness is limited.
community Meta analysis of minoxidil only vs 5AR inhibitors
Oral dutasteride is the most effective for hair regrowth, followed by oral finasteride and minoxidil. Topical finasteride combined with minoxidil is recommended for those avoiding systemic DHT reduction.
community My story (22m, fin, min, niz, RU, dut –> part frontal hair system)
User "hairplsrn" shares their hair loss journey, trying various treatments like finasteride, minoxidil, and dutasteride, but experiencing worsening hair loss. They decide to get a partial frontal hair system and continue medication, while others offer support and advice on staying on medication and focusing on overall confidence.
community Crazy idea: creatine + topical finasteride
Using topical finasteride with creatine might help reduce hair loss by targeting local DHT while maintaining normal systemic levels, but results are uncertain without testing. Users report mixed experiences with topical treatments like finasteride, dutasteride, RU58841, and minoxidil, with some seeing regrowth and others experiencing side effects.
community If you had to abandon DHT blockers, what’s next?
Users discuss alternatives to DHT blockers for hair loss, suggesting minoxidil, microneedling, natural DHT blockers, and scalp massages. Some explore RU58841, ketoconazole, hair transplants, and hair systems due to side effects from finasteride and dutasteride.
Related Research
6 / 6 results
research Systemic treatment options for androgenic alopecia
In this study, a systematic review found that for androgenetic alopecia, systemic treatments like finasteride, dutasteride, and oral minoxidil are effective at slowing progression and promoting hair regrowth, with additional antiandrogen therapy options for women.
research ALOPECIA ANDROGENÉTICA: DIAGNÓSTICO, TERAPIAS CLÍNICAS E PROCEDIMENTOS ESTÉTICOS
This study conducted a narrative literature review on androgenetic alopecia, highlighting the clinical diagnosis and management strategies, including minoxidil and 5-alpha-reductase inhibitors for men, and antiandrogens for women, along with the use of aesthetic procedures like microneedling as complementary therapies.
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research Nanostructured Drug Delivery Systems for Targeting 5-α-Reductase Inhibitors to the Hair Follicle
This review examines new formulations for delivering 5-α-reductase inhibitors to improve targeted drug delivery in androgenetic alopecia, but reports no new clinical results.
research Medications and hair transplantation
This review discusses the necessity for hair transplant surgeons to be well-versed in both surgical and medical treatments for various forms of alopecia, and it reports no new results.
research An Update on Hair Restoration
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