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GlossarySteroid Sulfatase (STS)

enzyme that converts sulfated steroids into active forms

Steroid Sulfatase (STS) is an enzyme that plays a crucial role in the metabolism of steroid hormones by converting sulfated steroid precursors into their active forms. This process is important for the regulation of various physiological functions, including skin health, hair growth, and reproductive processes. Deficiencies or mutations in the STS gene can lead to conditions such as X-linked ichthyosis, which is characterized by dry, scaly skin.

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A Novel Nonsense Mutation in the STS Gene in a Pakistani Family with X-Linked Recessive Ichthyosis: Including a Very Rare Case of Two Homozygous Female Patients

research A Novel Nonsense Mutation in the STS Gene in a Pakistani Family with X-Linked Recessive Ichthyosis: Including a Very Rare Case of Two Homozygous Female Patients

6 citations , January 2020 in “BMC Medical Genetics”

A new mutation in the STS gene causes X-linked ichthyosis, even in rare female cases.

research Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty

41 citations , March 2016 in “The Journal of Clinical Endocrinology & Metabolism”

In STSD patients, the body compensates for low androgen levels by increasing another enzyme's activity.

research Estrogenic Potential of 2-Alkyl-4-(Thio)Chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

37 citations , September 2003 in “Journal of Medicinal Chemistry”

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

451 citations , March 2005 in “Endocrine Reviews”

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations , August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

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community Don’t let them scare you from finasteride. 8 months

in Progress Pictures 270 upvotes 1 year ago

A user shared their 8-month progress using 1mg oral finasteride with no side effects and plans to start minoxidil. Another user commented that the results look great and suggested reconsidering starting minoxidil.

community 2 years of me being on fin+min

in Progress Pictures 1216 upvotes 5 months ago

The conversation discusses hair loss treatments, specifically the use of oral finasteride and topical minoxidil, with the user sharing their two-year progress and routine. The user experienced initial shedding but saw improvements after six months, and they recently started taking dutasteride.

community 6 months of fin + min. Best decision ever

in Progress Pictures 1642 upvotes 10 months ago

Using finasteride and minoxidil for six months led to improved hair density and appearance. A temporary decrease in libido was noted as a side effect.