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GlossarySteroid Sulfatase (STS)

enzyme that converts sulfated steroids into active forms

Steroid Sulfatase (STS) is an enzyme that plays a crucial role in the metabolism of steroid hormones by converting sulfated steroid precursors into their active forms. This process is important for the regulation of various physiological functions, including skin health, hair growth, and reproductive processes. Deficiencies or mutations in the STS gene can lead to conditions such as X-linked ichthyosis, which is characterized by dry, scaly skin.

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research Estrogenic Potential of 2-Alkyl-4-(Thio)Chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

37 citations, September 2003 in “Journal of Medicinal Chemistry”

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

451 citations, March 2005 in “Endocrine Reviews”

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations, August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

research Dermatosurgical Techniques for Repigmentation of Vitiligo

60 citations, April 2006 in “International Journal of Dermatology”

Surgical methods like suction blister grafting and split-thickness skin grafting are highly successful for vitiligo repigmentation, but choosing the right patients is crucial for success.

research Skin Grafting for the Treatment of Chronic Leg Ulcers: A Systematic Review in Evidence-Based Medicine

56 citations, March 2016 in “International Wound Journal”

Skin grafts are effective for chronic leg ulcers, especially autologous split-thickness grafts for venous ulcers, but more data is needed for diabetic ulcers.

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community Don’t let them scare you from finasteride. 8 months

in Progress Pictures 270 upvotes 4 months ago

A user shared their 8-month progress using 1mg oral finasteride with no side effects and plans to start minoxidil. Another user commented that the results look great and suggested reconsidering starting minoxidil.