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    Glossary Steroid Sulfatase Inhibitors

    block enzyme activity to reduce active steroid levels

    Steroid Sulfatase Inhibitors (STS inhibitors) are compounds that block the activity of the enzyme steroid sulfatase, which is involved in the conversion of sulfated steroid precursors into active steroids like estrogen. By inhibiting this enzyme, STS inhibitors can reduce the levels of active steroids, potentially offering therapeutic benefits in conditions like hormone-sensitive cancers and certain skin disorders.

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    1. Hydrocortisone Mild corticosteroid used on the skin and scalp
    2. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    3. Alfatradiol Weak form of estrogen applied to the scalp
    4. Neem Oil Oil from the neem tree, used in traditional remedies