Steroid Sulfatase Inhibitors

The document reviewed the role of steroid sulfatase (STS) in regulating local production of estrogens and androgens, highlighting its potential as a therapeutic target for estrogen- and androgen-dependent disorders, including cancers and androgenetic alopecia. It discussed the medicinal chemistry of STS inhibitors, focusing on their structure-activity relationships. The review covered both potent arylsulfamate-based irreversible inhibitors and newly discovered reversible inhibitors. The publication of the X-ray structure of STS was expected to enhance research efforts in developing these inhibitors.