research Reversible decreases of fertility in male Sprague-Dawley rats treated orally with finasteride, a 5α-reductase inhibitor
Finasteride temporarily lowers male rat fertility without affecting libido.
Search
forResearch
5 / 1000+ resultsresearch N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase
This study identified N-acyl arylsulfonamides, particularly N-(Boc-piperidine-4-carbonyl)-benzenesulfonamides, as steroid sulfatase inhibitors with improved cellular potency compared to previous compounds.
research Steroid sulfatase inhibitors
This review discusses the medicinal chemistry of steroid sulfatase inhibitors for estrogen- and androgen-dependent disorders but reports no new clinical results.
research Sulfatase inhibitors: a patent review
The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
research The Many Faces of Calcineurin Inhibitor Toxicity—What the FK?
This review describes the toxicities associated with calcineurin inhibitors, used in kidney transplantation, which include nephrotoxicity, cardiovascular and endocrine issues, and quality of life impacts, without reporting new clinical results.
Community Join
5 / 219 resultscommunity The fear mongering of 5AR inhibitors
The conversation discusses the fear-mongering around 5AR inhibitors like finasteride for hair loss, with some users arguing about the percentage and severity of side effects. The main point is that while some experience side effects, others believe these are reversible, and the focus should be on informed decision-making rather than spreading fear.
community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.
community My balding/recovery rollercoaster story so far. I've regrown and lost my hair like 8 times in the last few years. Developed gyno but luckily it's reversible for me. M27
A 27-year-old man experienced hair regrowth and gynecomastia from finasteride, leading to a cycle of stopping and restarting the treatment. He is considering gyno surgery and consulting an endocrinologist as potential solutions.
community Take licorice to lower testosterone?
Licorice is not recommended for hair loss as it inhibits hair growth and is a non-selective testosterone inhibitor. Alternatives like spironolactone are suggested for those considering hormonal treatments for hair loss.
community Prolactin the Cause of Hair Loss? ABS-201 the Cure?
Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.
Learn
— no results
Experts
— no results
Clinics
— no results