TLDR Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.
The study examined the relationship between SHBG gene variants and SHBG levels in 242 women with PCOS and 238 control women. It found significant associations between certain SHBG gene variants, particularly the rs727428 minor allele, and PCOS. Women with PCOS carrying this allele had increased levels of free and bioactive testosterone but no change in insulin resistance or serum lipids. The study also identified haplotypes that may influence susceptibility to PCOS. Despite the small sample size and focus on a specific ethnic group, the findings suggest that SHBG gene variants, especially rs727428, could contribute to the development of PCOS.
1265 citations,
October 2013 in “The Journal of Clinical Endocrinology and Metabolism” The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.
39 citations,
September 2012 in “Human Reproduction” Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.
633 citations,
September 1998 in “The Journal of Clinical Endocrinology and Metabolism” PCOS affects a similar percentage of Black and White women in the Southeastern United States.
58 citations,
November 2020 in “International Journal of Molecular Sciences” SHBG may be a useful early indicator and treatment target for PCOS.
1 citations,
May 2009 in “Wiley-Blackwell eBooks” Early treatment of PCOS in teens is crucial to prevent long-term health issues like diabetes and heart disease.
2 citations,
January 2012 in “Journal of metabolic syndrome” The document concludes that hirsutism can be managed with various treatments tailored to the individual, potentially improving quality of life.
9 citations,
March 2001 in “Clinics in dermatology” Hirsutism in women is often due to hormone sensitivity and has significant psychological effects.
39 citations,
September 2012 in “Human Reproduction” Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.
