Assessment of Diagnostic Competence of Plasmatic Androgens on Polycystic Ovary Syndrome Based on Receiver Operator Characteristic Curves

The study evaluated the accuracy of different androgens in diagnosing hyperandrogenemia in PCOS patients, using 55 PCOS patients and 27 healthy controls. It found that Free Testosterone Index (FTI) and bioavailable testosterone (BAT) had the highest diagnostic accuracy, with androstenedione (A) identifying an additional 5% of PCOS patients not detected by FTI, BAT, or total testosterone. The combination of FTI, BAT, and A diagnosed 96.36% of hyperandrogenemic patients. Dehydroepiandrosterone sulphate (DHEA-S) was deemed ineffective due to variable results. The study recommended including FTI, BAT, and A in routine PCOS androgen assessments and suggested further ROC curve analysis across a broader range of PCOS phenotypes to validate these findings.