Comparing Classic and Newer Phenotypes in Greek PCOS Women: The Prevalence of Metabolic Syndrome and Their Association with Insulin Resistance

    November 2012 in “ Journal of Endocrinological Investigation ”
    V. Vaggopoulos, Eftihios Trakakis, Charalampos Chrelias, Periklis Panagopoulos, George Basios, S. Makridima, Vasileios Sioulas, George Simeonides, G. Labos, Eleni Boutati, Dimitrios Kassanos
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    TLDR Greek women with classic PCOS are more likely to have metabolic syndrome and insulin resistance than those with newer PCOS types.
    The study compared the prevalence of metabolic syndrome (MS) and insulin resistance (IR) in 266 Greek women with polycystic ovary syndrome (PCOS), categorized into classic (Group 1) and newer (Group 2) phenotypes based on the Rotterdam criteria. It was found that 62.4% of the women had classic phenotypes, with a 19.6% prevalence of MS, while only 4.1% of the newer phenotypes had MS. Classic phenotypes also had a 3-fold higher percentage of impaired glucose tolerance and significantly higher HOMA-IR values and lower QUICKI values, indicating greater IR. The study concluded that Greek women with classic PCOS phenotypes are at a higher risk for MS and impaired glucose homeostasis than those with newer phenotypes, highlighting the need for early recognition and monitoring of women at risk for adverse health outcomes.
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