Transcriptomics Sequencing Reveals Qu-Shi-Yu-Fa Decoction Promotes Hair Cycle And Keratinization By Upregulating FOXN1 And TGM3 To Treat Androgenetic Alopecia

    May 2025 in “ Phytomedicine
    Mingxi Zhu, Yuan Fang, Ying Huang, W. QIU, Ling Ning, Yanan Li, Chengwei Zhu, Xiaoyu Song, Yuanyuan Wu, Wei Zou, Aiyun Wang, Lu Yin
    TLDR Qu-shi-yu-fa Decoction may help treat hair loss by promoting hair growth and strengthening.
    The study reveals that Qu-shi-yu-fa Decoction (QSYF), a traditional Chinese medicine formula, promotes hair cycle regulation and keratinization by upregulating the expression of FOXN1 and TGM3, providing therapeutic effects on androgenetic alopecia (AGA). This research offers new insights into the multi-target and multi-pathway mechanisms of Chinese medicine therapy for AGA, suggesting QSYF as a potential treatment option. The study emphasizes the need for alternative treatments due to the limited efficacy and side effects of current FDA-approved medications for AGA.
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