Single-Cell Transcriptomics Reveals the Natural Product Shi-Bi-Man Promotes Hair Regeneration by Activating the FGF Pathway in Dermal Papilla Cells

June 2022 in “ Phytomedicine ”

Mingrui Han, Cheng-Xi Li, Chenyang Zhang, Chenglin Song, Qiang Xu, Qianqian Liu, Jianming Guo, Yang-Kook Sun

Shi-Bi-Man FGF pathway dermal papilla cells hair regeneration alopecia finasteride minoxidil SBM Propecia Rogaine

TLDR Shi-Bi-Man helps hair regrowth by activating the FGF pathway in cells.

The study investigates the effects of the natural product Shi-Bi-Man (SBM) on hair regeneration, focusing on its activation of the FGF pathway in dermal papilla cells. Using C57BL/6 mice, the researchers administered SBM in both freeze-dried powder and solution forms, observing significant hair regrowth without toxicity. The findings suggest that SBM promotes hair growth by triggering the FGF signaling pathway, offering a potential alternative treatment for alopecia with fewer side effects compared to current FDA-approved drugs like finasteride and minoxidil.

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Research cited in this study

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