Single-Cell Transcriptomics Reveals the Natural Product Shi-Bi-Man Promotes Hair Regeneration by Activating the FGF Pathway in Dermal Papilla Cells

    June 2022 in “ Phytomedicine
    Mingrui Han, Cheng-Xi Li, Chenyang Zhang, Chenglin Song, Qiang Xu, Qianqian Liu, Jianming Guo, Yang-Kook Sun
    TLDR Shi-Bi-Man helps hair regrowth by activating the FGF pathway in cells.
    The study investigates the effects of the natural product Shi-Bi-Man (SBM) on hair regeneration, focusing on its activation of the FGF pathway in dermal papilla cells. Using C57BL/6 mice, the researchers administered SBM in both freeze-dried powder and solution forms, observing significant hair regrowth without toxicity. The findings suggest that SBM promotes hair growth by triggering the FGF signaling pathway, offering a potential alternative treatment for alopecia with fewer side effects compared to current FDA-approved drugs like finasteride and minoxidil.
    Discuss this study in the Community →

    Research cited in this study

    18 / 18 results

    Related Community Posts Join

    6 / 23 results

      community 18-year progress pics. Fin only.

      in Progress Pictures  419 upvotes 2 months ago
      The user has been using finasteride for 18 years to manage hair loss and is considering starting minoxidil and possibly a hair transplant. Despite some regrowth, they are exploring additional treatments like dutasteride and oral minoxidil due to continued hair thinning.

      community Seb derm is eating my hair?!?!

      in Chat  41 upvotes 9 months ago
      A 22-year-old male is experiencing hair loss due to seborrheic dermatitis, not male pattern baldness, and is seeking advice. Suggestions include using Nizoral, sulfate-free and ketoconazole shampoos, cutting hair short, using cold water, avoiding picking scabs, and trying selenium sulfide shampoo or finasteride.

      community How to take better of my hair?

      in Chat  2 upvotes 3 weeks ago
      The user is experiencing hair loss and has tried topical finasteride without success due to side effects. They are considering using essential oils like rosemary, castor, and peppermint, and have started using 0.5% Pyriltamide.

      community GT20029. Kintor Pharma’s Product

      in Research/Science  12 upvotes 2 years ago
      The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

      community 3 months on Minoxidil 5% once per day

      in Progress Pictures  990 upvotes 1 week ago
      The user experienced significant hair growth after using minoxidil 5% and finasteride 1.25mg daily for three months, despite initial shedding. They noted improved hair density, especially at the temples, and plan to manage excess hair growth on the forehead.

    Related Research

    6 / 6 results