TLDR Having a lot of gray hair and hair loss are linked to more severe COVID-19.
In a study by São Paulo State University involving 43,595 participants from Brazil, researchers discovered that alopecia and extensive gray hair were independently linked to more severe COVID-19 cases. The study analyzed responses from 39,789 controls, 2,332 suspected, and 1,474 confirmed COVID-19 cases, finding a higher prevalence of both conditions in confirmed patients. While confirming known risk factors such as older age, hypertension, obesity, diabetes, and heart disease, the study also identified extensive gray hair and alopecia as additional independent risk factors for severe COVID-19. Despite limitations like the absence of dermatological examination and non-discrimination of alopecia types, the associations' magnitude and corroboration with suspected cases lent credibility to the findings.
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June 2020 in “Journal of the American Academy of Dermatology” Global collaboration in dermatology improved data sharing and patient care during COVID-19.
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May 2020 in “Journal of The American Academy of Dermatology” Most COVID-19 patients in hospitals have androgenetic alopecia, more in men, suggesting a link between androgen sensitivity and severe COVID-19 symptoms.
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January 2020 in “Nature” Stress can cause hair to turn gray by depleting stem cells.
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October 2014 in “International Journal of Cardiology” People with alopecia are at higher risk for heart disease and have more heart-related risk factors.
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December 2020 in “Dermatological reviews” COVID-19 may worsen with androgens; anti-androgen drugs could help.
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May 2021 in “Dermatologic Therapy” Possible link between androgens and COVID-19 severity; more research needed.
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July 2021 in “Frontiers in Medicine” Proxalutamide significantly lowered hospital admissions for male COVID-19 patients compared to a placebo.
October 2024 in “Journal of Cosmetic Dermatology” Over half of young people in Saudi Arabia experience early gray hair, linked to factors like smoking, stress, and family history.
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January 2024 in “Nature communications” Activating TLR5 in the gut can extend lifespan and improve health in aged mice.