Mucosal TLR5 Activation Controls Healthspan and Longevity

    January 2024 in “ Nature communications ”
    J. Lim, Eun Jae Jeon, Hye Sun Go, Hyungjin Kim, Kye Young Kim, Thi Quynh Trang Nguyen, D. Lee, Kyu Suk Kim, Federico Pietrocola, Seol Hee Hong, Shee Eun Lee, Kyoung‐Shim Kim, Tae‐Shin Park, Dong‐Hee Choi, Yu‐Jin Jeong, Jong‐Hwan Park, Hyeon Sik Kim, Jung‐Joon Min, Yong Sook Kim, Joon Tae Park, Jae-Ho Cho, Gil-Woo Lee, Ji Hyeon Lee, Hyon E. Choy, Sang Chul Park, Chul‐Ho Lee, Joon Haeng Rhee, Manuel Serrano, Kyung A Cho
    Image of study
    TLDR Activating TLR5 in the gut can extend lifespan and improve health in aged mice.
    The study demonstrates that mucosal activation of Toll-like receptor 5 (TLR5) via a flagellin-containing fusion protein (FP) significantly extends lifespan and enhances healthspan in aged mice. This intervention improved various aging-related phenotypes, such as reduced hair loss, decreased ocular lens opacity, increased bone mineral density, improved stem cell activity, delayed thymic involution, enhanced cognitive function, and prevention of pulmonary fibrosis. The beneficial effects were linked to increased TLR5 expression and interleukin-22 (IL-22) secretion, which bolstered intestinal mucosal integrity. The findings suggest that TLR5-dependent mucosal stimulation could be a promising strategy for promoting healthy aging and longevity.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Hairloss is mentally exhausting

      in Chat  25 upvotes 3 years ago
      The conversation is about the mental toll of hair loss and seeking alternatives to finasteride. Suggestions include using minoxidil, considering pumpkin seed oil, and possibly seeking counseling for body dysmorphic disorder.

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes 2 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

    Similar Research

    5 / 1000+ results