Altered FGF Expression Profile in Human Scalp-Derived Fibroblasts Upon WNT Activation: Implication of Their Role in Providing a Folliculogenetic Microenvironment

    September 2020 in “ Inflammation and Regeneration ”
    Misaki Kinoshita‐Ise, Aki Tsukashima, Tomonari Kinoshita … Manabu Ohyama
    Studysummary In this study, researchers found that WNT activation influenced FGF expression in human scalp-derived fibroblasts, with mouse model results showing FGF9 increased hair follicle number and diameter, while FGF7 reduced diameter.
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    Research cited in this study 23

    1. Wnt Activator CHIR99021-Stimulated Human Dermal Papilla Spheroids Contribute to Hair Follicle Formation and Production of Reconstituted Follicle-Enriched Human Skin Biochemical and Biophysical Research Communications · 2019
    2. Use of Human Intra-Tissue Stem/Progenitor Cells and Induced Pluripotent Stem Cells for Hair Follicle Regeneration PubMed · 2019
    3. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017
    4. Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells Scientific Reports · 2017
    5. Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis Regeneration · 2015
    6. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    7. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    8. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    9. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    10. Development and Prospects of Organ Replacement Regenerative Therapy Cornea · 2013
    11. Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites Journal of Investigative Dermatology · 2013
    12. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    13. Position Effect on FGF13 Associated with X-Linked Congenital Generalized Hypertrichosis Proceedings of the National Academy of Sciences of the United States of America · 2013
    14. Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering Journal of Dermatological Science · 2013
    15. Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into the Molecular Basis of Hair Loss in Cetaceans BMC evolutionary biology · 2013
    16. Human Induced Pluripotent Stem Cell-Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    17. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    18. Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles International Journal of Molecular Medicine · 2011
    19. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    20. KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin Development · 2009
    21. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    22. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    23. Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia. PubMed · 1995

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