Traditional Chinese Medicine Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration

    July 2023 in “ Chinese Medicine ”
    Haojie Du, Tao Zhang, Qiao Wang … Yang Sun
    Studysummary This study found that Shi-Bi-Man significantly promotes hair regeneration in cynomolgus monkeys by increasing hair follicle stem cells and up-regulating metabolic pathways.
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    Research cited in this study 27

    1. The Burden of Alopecia Areata: A Scoping Review Focusing on Quality of Life, Mental Health, and Work Productivity Journal of the European Academy of Dermatology and Venereology · 2023
    2. Single-Cell Transcriptomics Reveals the Natural Product Shi-Bi-Man Promotes Hair Regeneration by Activating the FGF Pathway in Dermal Papilla Cells Phytomedicine · 2022
    3. Alpinetin Promotes Hair Regeneration via Activating Hair Follicle Stem Cells Chinese medicine · 2022
    4. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    5. Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities Signal Transduction and Targeted Therapy · 2022
    6. Modulation of Hair Growth Promoting Effect by Natural Products Pharmaceutics · 2021
    7. Growth Hormone and the Human Hair Follicle International journal of molecular sciences · 2021
    8. Keep Quiet—How Stress Regulates Hair Follicle Stem Cells Signal Transduction and Targeted Therapy · 2021
    9. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    10. Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions Nature communications · 2021
    11. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    12. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020
    13. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    14. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    15. Pediatric Androgenetic Alopecia: A Review Journal of The American Academy of Dermatology · 2019
    16. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    17. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    18. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    19. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    20. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    21. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    22. Bioactives in Chinese Proprietary Medicine Modulate 5α-Reductase Activity and Gene Expression Associated with Androgenetic Alopecia Frontiers in Pharmacology · 2017
    23. Ginsenoside Rg3 Up-Regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles PTR. Phytotherapy research/Phytotherapy research · 2013
    24. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    25. Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG) Phytomedicine · 2006
    26. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    27. Fibroblast Growth Factor and Epidermal Growth Factor in Hair Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993

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