Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis

    December 2022 in “ Research Square (Research Square) ”
    Qitao Chen, Qiuwei Tao, Yuqian Li … Xuewen Du

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, type I interferon response-related genes activated by RIG-1 and IL-17 signaling pathways were significantly up-regulated in both hair follicles and skin tissues affected by chronic discoidal lupus erythematosus.
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    Research cited in this study 4

    1. Plucked Hair Follicles From Patients With Chronic Discoid Lupus Erythematosus Show a Disease-Specific Molecular Signature Lupus Science & Medicine · 2019
    2. Cicatricial Alopecia: Overview and Treatment Recommendations Journal der Deutschen Dermatologischen Gesellschaft · 2018
    3. Primary Cicatricial Alopecia: Treatment Approaches and Classification Journal of The American Academy of Dermatology · 2016
    4. Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method British Journal of Dermatology · 2011