December 2022 in “Research Square (Research Square)” The study investigates gene expression in hair follicles affected by chronic discoid lupus erythematosus (CDLE) using bioinformatics methods. By analyzing data from 4 healthy and 7 CDLE-affected hair follicles, and validating with 13 healthy and 47 CDLE-affected scalp samples, the researchers identified key genes through differential expression and WGCNA. These genes, associated with type I interferon response and RIG-1 and IL-17 signaling pathways, were significantly upregulated in both hair follicles and skin tissues. The study also suggests the involvement of follicular helper T cells (Tfhs) in the disease process.
October 2022 in “Research Square (Research Square)” The study analyzed gene expression data from hair follicles affected by chronic discoid lupus erythematosus (CDLE) using bioinformatics methods. It identified key genes through differential gene expression analysis and weighted gene co-expression network analysis (WGCNA). The findings were validated with additional data from skin samples. The study found that type I interferon response-related genes, activated by the RIG-1 and IL-17 signaling pathways, were significantly up-regulated in CDLE-affected hair follicles and skin tissues. The involvement of follicular helper T cells (Tfhs) was also suggested in the disease process.
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April 2021 in “Cell Host & Microbe” Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.
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March 2024 in “Signal transduction and targeted therapy” NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
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May 2012 in “Hair transplant forum international” Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.