Lactate in Skin Homeostasis: Metabolism, Skin Barrier, and Immunomodulation

    February 2025 in “ Frontiers in Immunology ”
    Dan‐dan Ruan, T. Hu, Xiaoping Yang … Qiang Ju
    Studysummary This study highlights emerging research on lactate's biological roles in skin health, emphasizing its function as a signaling molecule that regulates skin barrier and immunity, and notes its therapeutic potential for skin conditions such as tumors and inflammatory diseases.
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    Research cited in this study 9

    1. Dissolving Microneedles for Alopecia Treatment Colloids and surfaces. B, Biointerfaces · 2023
    2. LSD1 Interacting With HSP90 Promotes Skin Wound Healing by Inducing Metabolic Reprogramming of Hair Follicle Stem Cells Through the c-MYC/LDHA Axis ˜The œFASEB journal · 2023
    3. A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy Advanced healthcare materials/Advanced Healthcare Materials · 2022
    4. Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase Scientific Reports · 2021
    5. The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside Frontiers in immunology · 2020
    6. Outer Root Sheath Is Able to Synthesize Glycogen from Lactate: Investigating Glycogen Metabolism in Human Hair Follicles Journal of Investigative Dermatology · 2019
    7. T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities British journal of dermatology/British journal of dermatology, Supplement · 2018
    8. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    9. Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells Journal of Investigative Dermatology · 1996