Lactate in Skin Homeostasis: Metabolism, Skin Barrier, and Immunomodulation

February 2025 in “ Frontiers in Immunology ”

Dan‐dan Ruan, T. Hu, Xiaoping Yang, Xiaohui Mo, Qiang Ju

lactate keratinocytes hair follicle stem cells skin barrier immune responses inflammation anti-inflammatory macrophage polarization alopecia wound healing skin aging hair loss skin health

Studysummary This study highlights emerging research on lactate's biological roles in skin health, emphasizing its function as a signaling molecule that regulates skin barrier and immunity, and notes its therapeutic potential for skin conditions such as tumors and inflammatory diseases.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on frontiersin.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Dissolving Microneedles for Alopecia Treatment

4 citations , July 2023 in “Colloids and surfaces. B, Biointerfaces”

This study explores novel alopecia treatments targeting lactate dehydrogenase pathways and improving drug delivery through technologies like phototherapy and soluble microneedles, though practical application challenges remain, necessitating further research for clinical use.

LSD1 Interacting With HSP90 Promotes Skin Wound Healing by Inducing Metabolic Reprogramming of Hair Follicle Stem Cells Through the c-MYC/LDHA Axis

research LSD1 Interacting With HSP90 Promotes Skin Wound Healing by Inducing Metabolic Reprogramming of Hair Follicle Stem Cells Through the c-MYC/LDHA Axis

1 citations , June 2023 in “The FASEB journal”

This study found that in mice, LSD1 interacting with HSP90 accelerates skin wound healing by enhancing HFSC glycolytic metabolism, proliferation, and differentiation via the c-MYC/LDHA axis.

research A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy

31 citations , July 2022 in “Advanced healthcare materials/Advanced Healthcare Materials”

In this study, researchers developed a drug-free microneedle patch using chitosan lactate and stem cell-derived exosomes that significantly promotes hair regeneration in animal tests compared to minoxidil, highlighting its potential as a simple and efficient hair loss treatment.

research Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase

30 citations , October 2021 in “Scientific Reports”

This study found that human scalp hair follicles can internally operate a Cori cycle, synthesize glycogen in the presence of lactate, and modulate growth through glycogen phosphorylase activity.

research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations , November 2020 in “Frontiers in immunology”

This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.

research Outer Root Sheath Is Able to Synthesize Glycogen from Lactate: Investigating Glycogen Metabolism in Human Hair Follicles

7 citations , September 2019 in “Journal of Investigative Dermatology”

T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities

research T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities

66 citations , March 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

This article reviews the role of perifollicular regulatory T cells in maintaining hair follicle integrity in the context of hidradenitis suppurativa and calls attention to inflammatory mechanisms without reporting new clinical results.

research Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation

202 citations , August 2017 in “Nature cell biology”

This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.

research Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells

135 citations , January 1996 in “Journal of Investigative Dermatology”