Dissolving Microneedles for Alopecia Treatment

July 2023 in “ Colloids and surfaces. B, Biointerfaces ”

Hong Xiang, Sheng Xu, Wei-Wei Zhang, Xinyue Xue, Yixuan Li, Ying Lv, Jing Chen, Xiao Miao

dissolving microneedles alopecia stratum corneum lactate dehydrogenase reactive oxygen hair follicles hair follicle stem cells MNs

TLDR Dissolving microneedles show promise for treating hair loss but need more research for practical use.

The paper discusses the limitations of current alopecia treatments, such as topical minoxidil and oral finasteride, which face issues like poor skin penetration and systemic side effects. It highlights the potential of dissolving microneedles (MNs) as a novel treatment strategy for alopecia. MNs improve drug delivery by enhancing transdermal penetration and targeting hair follicle stem cells, thus promoting hair regeneration. Despite their promising effects, challenges remain in their practical application, necessitating further research to facilitate clinical translation. The study underscores the importance of understanding alopecia mechanisms to develop effective treatments.

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