Novel Tip-Loaded Dissolving and Implantable Microneedle Array Patches for Sustained Release of Finasteride
July 2021
in “
International Journal of Pharmaceutics
”
finasteride androgenic alopecia microneedle array patches benign prostatic hyperplasia oral administration drug absorption side effects non-invasive delivery long-acting delivery polymers drug loading capacity mechanical resistance in vitro release sustained drug release Propecia microneedle patches BPH oral finasteride non-invasive long-acting drug capacity mechanical strength in vitro sustained release
TLDR New dissolving and implantable microneedle patches have been created for a long-lasting, non-invasive delivery of the drug finasteride.
The paper discusses the development of dissolving and implantable microneedle array patches for the sustained release of finasteride, a drug used for the treatment of benign prostatic hyperplasia and androgenic alopecia. The current oral administration of finasteride has limitations such as low absorption and side effects. The microneedle array patches, which consist of micro-projections that can penetrate the skin, offer a non-invasive and long-acting delivery method. The patches were formulated using polymers that dissolve or degrade in the skin, allowing for gradual release of the drug. The patches showed high drug loading capacity and mechanical resistance. In vitro release experiments demonstrated sustained drug release. This novel approach could potentially improve treatment adherence and patient compliance.
