Novel Tip-Loaded Dissolving and Implantable Microneedle Array Patches for Sustained Release of Finasteride

    July 2021 in “ International Journal of Pharmaceutics ”
    Alejandro Javier Paredes, Fabiana Volpe-Zanutto, Andi Dian Permana … Ryan F. Donnelly
    Studysummary This study describes the development of microneedle array patches for finasteride that released the drug over 7 to 14 days in vitro, suggesting a potential alternative to oral treatments for long-term management of benign prostatic hyperplasia and androgenic alopecia.
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    Research cited in this study 14

    1. Development and Ex-Vivo Skin Permeation Studies of Finasteride–Poly(Lactic Acid-Co-Glycolic Acid) and Minoxidil–Chitosan Nanoparticulate Systems Journal of Bioactive and Compatible Polymers · 2020
    2. Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia Journal of Controlled Release · 2019
    3. Enhancement of Dermal Delivery of Finasteride Using Microemulsion Systems Advanced Pharmaceutical Bulletin · 2019
    4. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia Skin Pharmacology and Physiology · 2017
    5. Preparation of Finasteride Capsules-Loaded Drug Nanoparticles: Formulation, Optimization, In Vitro, and Pharmacokinetic Evaluation International Journal of Nanomedicine · 2016
    6. Quality Evaluation of the Finasteride Polymorphic Forms I and II in Capsules Journal of Pharmaceutical and Biomedical Analysis · 2014
    7. The Immunology of the Porcine Skin and Its Value as a Model for Human Skin Molecular immunology · 2014
    8. In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers Aaps Pharmscitech · 2008
    9. Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation Pharmaceutical Development and Technology · 2007
    10. Effect of 1 mg/Day Finasteride on Concentrations of Serum Prostate-Specific Antigen in Men With Androgenic Alopecia: A Randomized Controlled Trial Lancet Oncology · 2006
    11. Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes International Journal of Pharmaceutics · 2006
    12. Structural Characterization of Polymorphs and Molecular Complexes of Finasteride Journal of Molecular Structure · 1999
    13. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride Clinical Pharmacokinectics · 1996
    14. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992

    Related research 1

    1. Transdermal Drug Delivery of Finasteride Ethosomes and Finasteride Liposomes Zhōnghuá yàoxué zázhì · 2007