Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment

May 2022 in “ Advanced therapeutics ”

You-Seong Kim, Yeong Ryu, Hye Sook Min, Huisuk Yang, Jeehye Nam, Chisong Lee, Daniel Junmin Um, Miji Kim, Paola Atzei, Rita de Brito Francisco, Reto Naef, Kyungeon Choi, Hyungil Jung

dissolving microneedles DMN TOP-M119 M119 vasodilator alopecia finasteride minoxidil hair follicles β-catenin proliferating cell nuclear antigen hair growth markers microneedles hair loss Propecia Rogaine hair growth

TLDR A new microneedle system effectively delivers a vasodilator to hair follicles, promoting hair growth better than current treatments.

Researchers have developed a novel drug delivery system using dissolving microneedles (DMN) loaded with TOP-M119 (M119), a vasodilator, for advanced alopecia treatment. This system addresses the limitations of current treatments like finasteride and minoxidil by enhancing drug delivery to hair follicles. The specially designed DMN and applicator ensure effective scalp implantation without accidental skin insertion. In vitro, ex vivo, and in vivo studies, including mouse models, demonstrated superior efficacy in promoting hair growth, supported by increased expression of hair growth markers such as β-catenin and proliferating cell nuclear antigen.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

38 citations, July 2021 in “ACS Nano”

Microneedles help treat hair loss by improving hair surroundings and promoting growth.

research KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis

13 citations, March 2021 in “British Journal of Pharmacology”

KY19382 helps regrow hair and create new hair follicles.

research Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride

40 citations, November 2020 in “JAMA Dermatology”

Finasteride may cause suicidal thoughts and mental side effects, especially in young people with hair loss.

research Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

35 citations, January 2020 in “Skin Pharmacology and Physiology”

The review concluded that keeping the hair-growing ability of human dermal papilla cells is key for hair development and growth.

research Finasteride and Suicide: A Postmarketing Case Series

6 citations, January 2020 in “Dermatology”

Finasteride may increase suicide risk; more research needed.

research Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia

33 citations, November 2019 in “Journal of Controlled Release”

Microneedles with enhancer effectively promote hair growth and increase hair density.

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations, April 2019 in “ACS nano”

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

research Novel Effect of Sildenafil on Hair Growth

16 citations, October 2018 in “Biochemical and Biophysical Research Communications”

Sildenafil, often used for erectile dysfunction, may help hair growth.

research Microneedling for the Treatment of Hair Loss

58 citations, December 2017 in “Journal of The European Academy of Dermatology and Venereology”

Microneedling can help stimulate hair growth, especially when used with other treatments, but it's not better than existing therapies.

research Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model

55 citations, January 2016 in “Annals of Dermatology”

Microneedle stimulation can increase hair growth in mice.

research Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study

69 citations, July 2015 in “Pharmacotherapy”

Low-dose finasteride may cause lasting sexual dysfunction and suicidal thoughts in young men.

research Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

23 citations, June 2014 in “Journal of Pharmaceutical Sciences”

Finasteride cream helps hair growth with less side effects.

research Hair Growth and Rejuvenation: An Overview

81 citations, June 2010 in “Journal of Dermatological Treatment”

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations, February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

Related Research

10 / 10 results

research A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss

1 citations, October 2022 in “PubMed”

Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations, August 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Scalp Threading – New Treatment Option for Androgenetic Alopecia

June 2022 in “South Florida Journal of Health”

Scalp Threading is a promising new treatment for hair loss that may work better than current options.

research Scalp Vascularization as a Marker of Topical Minoxidil Treatment Efficacy in Patients with Androgenetic Alopecia

March 2021 in “Postepy Dermatologii I Alergologii”

Minoxidil works equally well for hair growth regardless of scalp blood flow.

research Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis

1 citations, October 2020 in “Journal of Cosmetic Dermatology”

Using minoxidil and tofacitinib together can effectively treat severe hair loss.

research Oral Minoxidil Improves Background Hair Thickness in Lichen Planopilaris

15 citations, April 2020 in “Journal of The American Academy of Dermatology”

Oral minoxidil can increase or maintain hair thickness in most people with lichen planopilaris, with mild side effects.

research Hair Disorders

August 2018 in “Oxford University Press eBooks”

The document's conclusion cannot be provided because the document cannot be parsed.

research Pustular Dermatosis of the Scalp Due to Topical Minoxidil 5%

3 citations, January 2018

A woman had an unusual allergic reaction to a hair loss treatment, which cleared up after stopping the treatment and using a different medication.

research Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment

14 citations, January 2015 in “Skin appendage disorders”

Minoxidil treatment for hair loss can cause scalp allergy and severe hair loss.

research Disorders of Hair

July 2013 in “DeckerMed Medicine”

The document's conclusion cannot be provided because the document is not readable or understandable.