Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment

    May 2022 in “ Advanced therapeutics ”
    You-Seong Kim, Yeong Ryu, Hye Sook Min … Hyungil Jung
    Studysummary This study reported that a novel vasodilator drug called TOP-M119, when delivered using a specially designed dissolving microneedle system, showed enhanced targeting of hair follicles and effectiveness in treating alopecia, demonstrated through in vitro, ex vivo, and in vivo studies involving mouse skin.
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    Research cited in this study 15

    1. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    2. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    3. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    4. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    5. Finasteride and Suicide: A Postmarketing Case Series Dermatology · 2020
    6. Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia Journal of Controlled Release · 2019
    7. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    8. Novel Effect of Sildenafil on Hair Growth Biochemical and Biophysical Research Communications · 2018
    9. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    10. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model Annals of Dermatology · 2016
    11. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    12. Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014
    13. Hair Growth and Rejuvenation: An Overview Journal of Dermatological Treatment · 2010
    14. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    15. Local Injection of Steroids and Hair Regrowth in Alopecias Archives of Dermatology · 1960

    Related research 10

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    3. Scalp Threading – New Treatment Option for Androgenetic Alopecia South Florida Journal of Health · 2022
    4. Scalp Vascularization as a Marker of Topical Minoxidil Treatment Efficacy in Patients with Androgenetic Alopecia Postepy Dermatologii I Alergologii · 2021
    5. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
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