A Lipid–Polymer Hybrid Nanoparticle-Loaded Dissolving Microneedle Patch for Promoting Hair Regrowth by Transdermal miR-218 Delivery

    November 2022 in “ Biomaterials Science
    Yipu Zhao, Ye Tian, Weiliang Ye, Xue Wang, Ying Huai, Qian Huang, Xiaohua Chu, Xudong Deng, Airong Qian
    TLDR The microneedle patch effectively promotes hair regrowth by delivering miR-218.
    The study investigates a novel dissolving microneedle (MN) patch loaded with lipid–polymer hybrid nanoparticles (LPNs) for transdermal delivery of miR-218 to promote hair regrowth. This approach addresses alopecia by activating the Wnt/β-catenin pathway, crucial for hair follicle transformation. The MN patches, made from hyaluronic acid, enhance skin permeability and protect miR-218 from degradation. In vivo tests on mice showed that the MN patches significantly accelerated hair regrowth and increased hair thickness compared to traditional methods, effectively transitioning hair follicles from the telogen to anagen phase. The study concludes that the MN/LPN system is a promising non-invasive method for localized miR-218 delivery to treat hair loss.
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