Bletilla Striata Polysaccharide-Based Dissolving Microneedle Patch Integrated with Nanoparticles for Promoting Hair Regrowth

    Yanyan Zhao, Jicheng Wang, Ying Zhang … Weifen Zhang
    Studysummary This study found that a microneedle patch containing tofacitinib-loaded nanoparticles significantly increased hair follicle numbers and promoted hair regeneration with less drug compared to daily topical tofacitinib, suggesting it may be an effective strategy for alopecia treatment by reducing dosing frequency and enhancing drug delivery.
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    Research cited in this study 30

    1. Fabrication of Composite Pastes with Minoxidil-Loaded Nanoparticles and Valproic Acid for Androgenetic Alopecia Treatment International Journal of Biological Macromolecules · 2023
    2. Duo-Role Platelet-Rich Plasma: Temperature-Induced Fibrin Gel and Growth Factors' Reservoir for Microneedles to Promote Hair Regrowth Journal of Advanced Research · 2023
    3. Advances in Microneedles Research Based on Promoting Hair Regrowth Journal of Controlled Release · 2022
    4. A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch Bioactive Materials · 2022
    5. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    6. The Efficacy and Safety of JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis of Prospective Studies Frontiers in pharmacology · 2022
    7. A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy Advanced healthcare materials/Advanced Healthcare Materials · 2022
    8. Dissolving Microneedles: Applications and Growing Therapeutic Potential Journal of Controlled Release · 2022
    9. Baricitinib in Alopecia Areata New England Journal of Medicine · 2022
    10. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    11. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    12. Review of Oral Minoxidil as Treatment of Hair Disorders: In Search of the Perfect Dose 2021
    13. Side Effects of Low-Dose Oral Minoxidil for Treating Alopecia Journal of The American Academy of Dermatology · 2021
    14. The Inflammatory Aspect of Male and Female Pattern Hair Loss Journal of Inflammation Research · 2020
    15. Benefit and Risk Profile of Tofacitinib for the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the European Academy of Dermatology and Venereology · 2019
    16. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    17. Minoxidil for Patchy Alopecia Areata: Systematic Review and Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2019
    18. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    19. Novel Effect of Sildenafil on Hair Growth Biochemical and Biophysical Research Communications · 2018
    20. Tofacitinib for the Treatment of Alopecia Areata in Preadolescent Children Journal of the American Academy of Dermatology · 2018
    21. Simultaneous Improvement of Alopecia Universalis and Atopic Dermatitis in a Patient Treated with a JAK Inhibitor JAAD case reports · 2018
    22. Topical 2% Tofacitinib for Children with Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Journal of the American Academy of Dermatology · 2018
    23. Randomized Trial of Electrodynamic Microneedle Combined with 5% Minoxidil Topical Solution for the Treatment of Chinese Male Androgenetic Alopecia Journal of Cosmetic and Laser Therapy · 2017
    24. Efficacy of Topical Tofacitinib in Promoting Hair Growth in Non-Scarring Alopecia: Possible Mechanism via VEGF Induction Archives of Dermatological Research · 2017
    25. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    26. Systemic Causes of Hair Loss Annals of Medicine · 2016
    27. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model Annals of Dermatology · 2016
    28. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    29. The Psychology of Hair Loss and Its Implications for Patient Care Clinics in Dermatology · 2001
    30. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001