Bletilla Striata Polysaccharide-Based Dissolving Microneedle Patch Integrated with Nanoparticles for Promoting Hair Regrowth

    Yanyan Zhao, Jicheng Wang, Ying Zhang, Chunhui Liu, Yuqian Chen, Pan Li, Tailin Xu, Lina Gao, Weifen Zhang
    TLDR A new microneedle patch effectively promotes hair regrowth with less frequent dosing.
    The study presents a novel dissolving microneedle patch (TFB@NP-MNs) designed for hair regrowth, integrating tofacitinib-loaded nanoparticles with hyaluronic acid and Bletilla striata polysaccharide. This patch offers a promising strategy for alopecia treatment by enhancing drug delivery efficiency and patient compliance. It provides sustained release of tofacitinib for 48 hours, significantly increasing hair follicle numbers with less drug compared to daily topical applications. The microneedles penetrate the skin, delivering the drug effectively while also providing mechanical stimulation, which contributes to hair regrowth. The patch's biocompatibility and ability to reduce dosing frequency make it a potential clinical solution for hair loss therapy.
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