Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Tofacitinib for Treating Alopecia Areata

July 2024 in “ Journal of Controlled Release ”

Qibin Li, Yameng Wang, Qing Guo, Jie Cao, Yangjun Feng, Xue Ke

nanostructured lipid carriers percutaneous absorption hair follicle targeting tofacitinib alopecia areata IFN-γ JAK/STAT pathway topical formulation NLCs topical tofacitinib

From the encyclopedia

Tofacitinib →

a JAK inhibitor for alopecia areata and other autoimmune conditions

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary In this study, researchers developed topical tofacitinib-loaded cationic lipid nanoparticles, which improved absorption and targeted hair follicles in an ex vivo pig ear model, showing promise in treating alopecia areata by reducing symptoms through the JAK/STAT pathway. Our plain-language summary of this paper — not a Tressless recommendation.

The study developed tofacitinib-loaded cationic lipid nanoparticles (TFB-cNLCs) to enhance percutaneous absorption and hair follicle targeting for treating alopecia areata. Using ex vivo pig ear and in vitro follicle models, TFB-cNLCs demonstrated improved drug delivery to hair follicles, reduced IFN-γ-induced symptoms, and decreased CD8+NKG2D+T cells in a C3H mouse model, effectively reversing hair loss. This formulation offers a promising topical treatment, minimizing systemic side effects while maintaining efficacy.

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Research cited in this study

18 / 18 results

research Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata

42 citations , April 2021 in “JCI insight”

In this study, selective inhibition of JAK3 signaling effectively prevented and reversed alopecia areata in a mouse model, while JAK2 inhibitors did not restore hair growth.

research Jak Inhibitors: Uses In Dermatology. Part 1: Overview, Applications In Vitiligo And Alopecia Areata

20 citations , December 2020 in “Actas Dermo-Sifiliográficas”

This review examines the JAK/STAT signaling pathway's significance in inflammatory skin diseases and evaluates the efficacy and safety of oral and topical JAK inhibitors for treating vitiligo and alopecia areata. Results are not reported in this study.

research Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

15 citations , November 2020 in “Pharmaceutics”

In this ex vivo and mouse model study, Tofacitinib-loaded nanoparticles demonstrated enhanced delivery of the drug into hair follicles and reduced inflammatory effects compared to conventional forms, indicating potential for safer, topical use in treating alopecia areata.

research JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis

130 citations , February 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This study found that JAK inhibitors for alopecia areata showed promising response rates, with 72.4% of 289 cases responding, and oral administration achieving better outcomes than topical treatment, but recurrence occurred when treatment stopped. Further large-scale studies are needed to confirm these findings.

research JAK Inhibitors for Treatment of Alopecia Areata

63 citations , July 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this review, the researchers reported that JAK inhibitors, originally approved by the FDA for other uses, have shown effectiveness in reversing hair loss in patients with moderate to severe alopecia areata, based on current preclinical and clinical studies.

research A Simple Method Using Ex Vivo Culture of Hair Follicle Tissue to Investigate Intrinsic Circadian Characteristics in Humans

12 citations , July 2017 in “Scientific reports”

In this study, researchers developed a simple, non-invasive method to monitor circadian gene expression using whole hair root cultures, finding that elderly dementia patients' peripheral clocks still oscillate similarly to younger, healthier individuals, which suggests cellular senescence minimally affects some aspects of circadian rhythms.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations , April 2016 in “Journal of Investigative Dermatology”

This study found that STAT5 activation in the dermal papilla acts as a key switch to trigger anagen entry in postdevelopmental hair follicle cycling.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations , October 2015 in “Science Advances”

This study observed that applying JAK-STAT pathway inhibitors to mouse and human skin led to rapid hair growth by inducing the anagen phase of hair follicles.

Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia

research Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia

42 citations , July 2015 in “Drug Development and Industrial Pharmacy”

This study concluded that Flutamide-loaded solid lipid nanoparticles may enhance hair follicle drug delivery and promote hair growth in androgenic alopecia compared to a Flutamide hydroalcoholic solution.

research Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle

59 citations , January 2015 in “Nanoscale”

In this study, polymeric micelles containing retinoic acid were found to improve targeted delivery to hair follicle structures in human skin more efficiently than a marketed retinoic acid gel, suggesting potentially safer and more effective acne treatment.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.

research Quantification of Nanoparticle Uptake Into Hair Follicles in Pig Ear and Human Forearm

110 citations , January 2014 in “Journal of Controlled Release”

Phospholipid-coated nanoparticles penetrate hair follicles better than others, especially in pig ears.

research Investigation of Follicular and Non-Follicular Pathways for Polyarginine and Oleic Acid-Modified Nanoparticles

47 citations , November 2012 in “Pharmaceutical research”

This study found that surface modified nanoparticles showed increased skin permeation and improvement in allergic contact dermatitis, independent of the follicular pathway.

Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

research Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

59 citations , October 2012 in “Pharmaceutical Research”

This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.

research Selective Follicular Targeting by Modification of the Particle Sizes

263 citations , February 2011 in “Journal of Controlled Release”

This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.

research Alopecia Areata Update

244 citations , January 2010 in “Journal of the American Academy of Dermatology”

This review discusses treatment options for alopecia areata and suggests tailored treatment plans, noting the challenges posed by spontaneous remission and limited high-quality clinical trials.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

This study found that dermal papilla and peribulbar dermal sheath cup cells in mice can both induce hair follicle formation, suggesting they may have similar functional roles in hair growth.