TLDR MSC-Exos can aid organ development and offer therapeutic benefits for various conditions.
The document reviewed the role of mesenchymal stem cell-derived exosomes (MSC-Exos) in organ development and their potential as cell-free therapeutic agents. It highlighted that MSC-Exos can mediate intercellular communication during the organogenesis of structures like the salivary gland, tooth, hair follicle, and kidney. The review also discussed the therapeutic benefits of MSC-Exos in conditions such as ischemic heart disease, cutaneous wound healing, and COVID-19. The authors provided a critical analysis of exosome biogenesis, molecular composition, isolation, and characterization, and emphasized the reparative potential and mechanisms of action of MSC-Exos, while also addressing major challenges in the field.
65 citations,
July 2020 in “Science Advances” Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
58 citations,
March 2019 in “Experimental Dermatology” Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
113 citations,
November 2017 in “Scientific Reports” Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.
33 citations,
September 2012 in “Wound Repair and Regeneration” Applying calreticulin can speed up wound healing in diabetics.
417 citations,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
277 citations,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
47 citations,
February 2021 in “Pharmacological research” Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.
March 2024 in “Biomedicines” Mesenchymal stem cells show promise for effective skin repair and regeneration.
December 2023 in “Regenerative therapy” miRNA-based therapies show promise for treating skin diseases, including hair loss, in animals.
28 citations,
April 2023 in “Stem cell research & therapy” Tiny vesicles from stem cells could be a new treatment for healing wounds.
4 citations,
December 2022 in “Frontiers in Bioengineering and Biotechnology” Exosomes show promise for improving wound healing, reducing aging signs, preventing hair loss, and lightening skin but require more research and better production methods.
