TLDR MSC-Exos can aid organ development and offer therapeutic benefits for various conditions.
The document reviewed the role of mesenchymal stem cell-derived exosomes (MSC-Exos) in organ development and their potential as cell-free therapeutic agents. It highlighted that MSC-Exos can mediate intercellular communication during the organogenesis of structures like the salivary gland, tooth, hair follicle, and kidney. The review also discussed the therapeutic benefits of MSC-Exos in conditions such as ischemic heart disease, cutaneous wound healing, and COVID-19. The authors provided a critical analysis of exosome biogenesis, molecular composition, isolation, and characterization, and emphasized the reparative potential and mechanisms of action of MSC-Exos, while also addressing major challenges in the field.
65 citations,
July 2020 in “Science Advances” Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
58 citations,
March 2019 in “Experimental Dermatology” Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
113 citations,
November 2017 in “Scientific Reports” Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.
33 citations,
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417 citations,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
277 citations,
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47 citations,
February 2021 in “Pharmacological research” Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.
March 2025 in “World Journal of Stem Cells” Stem cell exosomes may help treat hair loss by promoting hair growth.
January 2024 in “Journal of tissue engineering” Sunlight exposure damages hair follicles, but certain stem cell-derived particles can reduce this damage and help with hair regeneration.
April 2024 in “Biomolecules” Exosomal miRNAs from stem cells can help improve skin health and delay aging.
3 citations,
October 2023 in “Frontiers in physiology” ceRNA networks offer potential treatments for skin aging and wound healing.
