Mitochondria-Targeted Biophysical Priming of Autologous Biologics for Skin Regeneration and Wound Repair

The review discusses the potential of mitochondria-targeted biophysical priming of autologous biologics, such as platelet-rich plasma (PRP) and mesenchymal stromal/stem cell (MSC)-based therapies, for skin regeneration and wound repair. Mitochondrial dysfunction is identified as a key factor in skin aging and chronic wounds. The review suggests using biophysical modalities like photobiomodulation (PBM), ultrasound, and mechanical stimulation to enhance mitochondrial function in these biologics, aiming to improve skin rejuvenation and wound healing outcomes. While these methods show promise, further studies are needed to establish standardized protocols and confirm efficacy. The approach aligns with minimal-manipulation regulatory frameworks, enhancing therapeutic potency without compromising safety.