Systems for Mitochondria-Protective Cosmetic Actives: Opportunities in Post-Oncologic Skin Regeneration

The document reviews the challenges faced by post-oncologic skin, such as mitochondrial dysfunction and oxidative stress, which result from cancer treatments like chemotherapy and radiotherapy. These issues lead to skin dryness, sensitivity, and impaired regeneration, affecting patients' quality of life. The review emphasizes the potential of mitochondria-protective cosmetic actives, such as Coenzyme Q10 and astaxanthin, to mitigate these effects by enhancing mitochondrial integrity and reducing oxidative stress. However, the efficacy of these compounds is often limited by poor skin penetration and stability. Advanced delivery systems, like lipid-based nanocarriers, are highlighted as promising strategies to improve the performance of these cosmetic actives by enhancing stability, penetration, and controlled release. These systems, including liposomes and nanostructured lipid carriers, are crucial for improving ingredient stability and modulating release profiles, making them promising carriers for dermocosmetic formulations aimed at supporting skin recovery and overall well-being in post-oncologic patients.