Potential of Nano-Encapsulation of Antioxidant Molecules in Wound Healing Applications: An Innovative Strategy to Enhance the Bio-Profile

    January 2025 in “ Molecules ”
    Supandeep Singh Hallan, Francesca Ferrara, Rita Cortesi, Maddalena Sguizzato
    TLDR Combining polymers and lipids may improve antioxidant delivery for wound healing, but practical challenges remain.
    The document explores the potential of nano-encapsulation of antioxidant molecules for wound healing, focusing on lipid-based nanoparticles like solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). These systems enhance drug delivery by improving skin permeation, stability, and targeted release of antioxidants, which can accelerate wound healing by promoting collagen formation and reducing inflammation. Challenges include low molecular weight, poor solubility, and inadequate skin permeability of antioxidants, as well as difficulties in scaling up production. The study suggests combining lipid and polymer-based transporters and using secondary vehicles like gels or sprays to enhance application and facilitate commercial transition. Techniques like SAXS and MD simulations are recommended for optimizing design and scalability.
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