Therapeutic Potential of Chitosan-Based and Related Nanocomposite Systems in Wound Management: A Review

This review highlights the therapeutic potential of chitosan-based nanocomposite systems, particularly when combined with polyphenols, in managing chronic wounds, such as those associated with diabetes. The integration of nanotechnology enhances the bioavailability and controlled release of polyphenols, overcoming their poor solubility and chitosan's limited stability. These systems exhibit regenerative, antioxidant, and antimicrobial properties, promoting angiogenesis, fibroblast growth, and epithelial regeneration while reducing infection-related complications. Although most studies are preclinical, the evidence suggests these systems could lead to effective clinical therapies for chronic and diabetic wounds.