Pharmacological And Biological Efficacy Of Chitosan-Based Materials

Chitosan-based materials, derived from chitin, have shown significant promise in biomedical applications due to their biocompatibility, biodegradability, and pharmacological activities. This review highlights their efficacy in treating non-communicable diseases and wound healing, with properties such as anticancer, anti-inflammatory, antidiabetic, antihypertensive, and neuroprotective effects. Chitosan serves as an effective drug carrier, enhancing drug delivery and selectivity while reducing toxicity. In wound healing, chitosan formulations like hydrogels and dressings demonstrate antibacterial, anti-inflammatory, and tissue-regenerative properties, achieving over 99.5% eradication of infections like MRSA and promoting rapid repair with hair follicle regeneration. Despite promising results in animal models and clinical trials, further research is needed for clinical and regulatory adoption, with 190 clinical studies currently exploring these materials. Future research should focus on large-scale validation and advanced biofabrication techniques to enhance clinical translation and ensure safety.