Normal-Pressure-Prepared Chitosan Carbonate Liquid Dressing: Spontaneous Transformation Into a Pure Chitosan Water-Resistant Film and Enhanced Wound Repair

The study introduces a novel chitosan carbonate (CS-CO2) liquid dressing that transforms into a water-resistant film, enhancing wound repair. It overcomes previous limitations of chitosan applications by avoiding cytotoxic residues and the need for alkaline neutralization. In vivo tests on 20 rats demonstrated that the CS-CO2 dressing promotes wound healing, with significant cell growth, low hemolysis rates, and antibacterial activity against S. aureus, E. coli, and P. aeruginosa. It outperformed commercial products like 3M Cavilon by promoting full-thickness wound regeneration, including hair follicle formation, within 10 days. The dressing minimizes inflammation and supports collagen deposition, making it a promising material for liquid wound dressings due to its stability, biocompatibility, and enhanced wound healing properties. Future research will focus on enhancing film adhesion and optimizing large-scale production for clinical use.